FHIT Antikörper (AA 1-147)

Produktnummer ABIN3031002

Produktdetails anti-FHIT Antikörper

Target: FHIT (Fragile Histidine Triad (FHIT))

Bindungsspezifität: AA 1-147

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FHIT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Antigen affinity

Immunogen: Human partial recombinant protein (AA 1-147) was used as the immunogen for this FHIT antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the FHIT antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the FHIT antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu FHIT

Target: FHIT (Fragile Histidine Triad (FHIT))

Andere Bezeichnung: FHIT (FHIT Produkte)

Synonyme: AP3Aase antikoerper, FRA3B antikoerper, FHIT antikoerper, zgc:73176 antikoerper, AW045638 antikoerper, Fra14A2 antikoerper, LOC100223655 antikoerper, fragile histidine triad antikoerper, fragile histidine triad gene antikoerper, fragile histidine triad protein antikoerper, fragile histidine triad L homeolog antikoerper, FHIT antikoerper, Fhit antikoerper, fhit antikoerper, PY07476 antikoerper, fhit.L antikoerper

Hintergrund: Bis(5'-adenosyl)-triphosphatase, also known as fragile histidine triad protein (FHIT) is an enzyme that in humans is encoded by the FHIT gene. This gene, a member of the histidine triad gene family, encodes a diadenosine P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3p14.2, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Furthermore, FHIT has been shown to synergize with VHL, another tumor suppressor, in protecting against chemically - induced lung cancer. It also acts as a tumor suppressor of HER2/neu driven breast cancer.

Gen-ID: 2272