FOXP1 Antikörper (C-Term)

Produktnummer ABIN3030994

Produktdetails anti-FOXP1 Antikörper

Target: FOXP1 (Forkhead Box P1 (FOXP1))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FOXP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Antigen affinity

Immunogen: An amino acid sequence from the C-terminus of human FOXP1 (HSPDFDHDRDYEDEPVNEDME) was used as the immunogen for this FOXP1 antibody (100% homologous in human, mouse and rat).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the FOXP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the FOXP1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu FOXP1

Target: FOXP1 (Forkhead Box P1 (FOXP1))

Andere Bezeichnung: FOXP1 (FOXP1 Produkte)

Synonyme: 12CC4 antikoerper, QRF1 antikoerper, hFKH1B antikoerper, 3110052D19Rik antikoerper, 4932443N09Rik antikoerper, AI461938 antikoerper, AW494214 antikoerper, foxp1 antikoerper, im:7139058 antikoerper, wu:fc83a06 antikoerper, FOXP1 antikoerper, MGC145686 antikoerper, 12cc4 antikoerper, fkh1b antikoerper, hspc215 antikoerper, qrf1 antikoerper, xlfoxp1 antikoerper, im:7146611 antikoerper, wu:fb97f01 antikoerper, zgc:154010 antikoerper, forkhead box P1 antikoerper, forkhead box P1b antikoerper, forkhead box P1 S homeolog antikoerper, forkhead box P1a antikoerper, FOXP1 antikoerper, Foxp1 antikoerper, foxp1b antikoerper, foxp1 antikoerper, foxp1.S antikoerper, foxp1a antikoerper

Hintergrund: Forkhead box P1 is a gene that is necessary for the proper development of the brain and lung in mammals. It is a member of the large FOX family of transcription factors. This gene belongs to subfamily P of the forkhead box(FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region(3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. It was shown that the embryonic stem cell(ESC)-specific isoform of FOXP1 stimulates the expression of transcription factor genes required for pluripotency, including OCT4, NANOG, NR5A2, and GDF3, while concomitantly repressing genes required for ESC differentiation. This isoform also promotes the maintenance of ESC pluripotency and contributes to efficient reprogramming of somatic cells into induced pluripotent stem cells. These results reveal a pivotal role for an Alternative splicing event in the regulation of pluripotency through the control of critical ESC-specific transcriptional programs(2).

UniProt: Q9H334

Pathways: Chromatin Binding, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response