Fascin Antikörper (N-Term)

Produktnummer ABIN3030912

Produktdetails anti-Fascin Antikörper

Target: Fascin (FSCN1)

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Fascin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Antigen affinity

Immunogen: An amino acid sequence from the N-terminus of human Fascin (DDGRWSLQSEAHRRYFG) was used as the immunogen for this Fascin antibody (100% homologous in human, mouse and rat).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the Fascin antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the Fascin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu Fascin

Target: Fascin (FSCN1)

Andere Bezeichnung: Fascin (FSCN1 Produkte)

Synonyme: CG15331 antikoerper, CG1536 antikoerper, CG32858 antikoerper, Dmel\\CG32858 antikoerper, SN antikoerper, Sn antikoerper, fs(1)A1057 antikoerper, fs(1)K1421 antikoerper, fs(1)K418 antikoerper, fs(1)K473 antikoerper, fs(1)K743 antikoerper, fs(1)M45 antikoerper, p55 antikoerper, snl antikoerper, MGC75811 antikoerper, fscn1 antikoerper, sb:cb589 antikoerper, zgc:153632 antikoerper, AI663989 antikoerper, Fan1 antikoerper, fascin-1 antikoerper, Fascin antikoerper, fscn antikoerper, FAN1 antikoerper, HSN antikoerper, SNL antikoerper, fascin antikoerper, singed antikoerper, fascin actin-bundling protein 1 antikoerper, fascin actin-bundling protein 1a antikoerper, fascin actin-bundling protein 1 L homeolog antikoerper, sn antikoerper, fscn1 antikoerper, fscn1a antikoerper, Fscn1 antikoerper, fscn1.L antikoerper, FSCN1 antikoerper

Hintergrund: Fascin is a actin cross-linking protein. The gene contains 5 exons and spans 7 kb. It is a 54-58 kilodalton monomeric actin filament bundling protein originally isolated from sea urchin egg but also found in Drosophila and vertebrates, including humans. Fascin is spaced at 11 nanometre intervals along the filament. The bundles in cross section are seen to be hexagonally packed, and the longitudinal spacing is compatible with a model where fascin cross-links at alternating 4 and 5 actins. It is calcium insensitive and monomeric. Fascin binds beta-catenin, and colocalizes with it at the leading edges and borders of epithelial and endothelial cells. The role of Fascin in regulating cytoskeletal structures for the maintenance of cell adhesion, coordinating motility and invasion through interactions with signalling pathways is an active area of research especially from the cancer biology perspective. Abnormal fascin expression or function has been implicated in breast cancer, colon cancer, esophageal squamous cell carcinoma, gallbladder cancer and prostate cancer.

UniProt: Q16658