DISC1 Antikörper (Middle Region)

Produktnummer ABIN3030744

Produktdetails anti-DISC1 Antikörper

Target: DISC1 (Disrupted in Schizophrenia 1 (DISC1))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DISC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Antigen affinity

Immunogen: An amino acid sequence from the middle region of human Disrupted in Schizophrenia 1 (EKQQLQKEIEALQARMF) was used as the immunogen for this DISC1 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the DISC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,Mouse

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the DISC1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu DISC1

Target: DISC1 (Disrupted in Schizophrenia 1 (DISC1))

Andere Bezeichnung: DISC1 (DISC1 Produkte)

Synonyme: DISC1 antikoerper, C1orf136 antikoerper, SCZD9 antikoerper, disrupted in schizophrenia 1 antikoerper, disrupted in schizophrenia 1 protein antikoerper, disc1 antikoerper, DISC1 antikoerper, LOC100580606 antikoerper, Disc1 antikoerper

Hintergrund: Disrupted in Schizophrenia 1 is a protein that is encoded by the DISC1 gene in humans. Ma et al.(2002) determined that the mouse gene maps to chromosome 8 in a region with homology of synteny to human chromosome 1q42. Ozeki et al.(2003) demonstrated that rodent Disc1 expression displayed pronounced developmental regulation, with the highest levels in late embryonic life during development of the cerebral cortex. Millar et al.(2005) showed that the protein interacts with the UCR2 domain of phosphodiesterase-4B, implicated in susceptibility to schizophrenia, and that elevation of cellular cAMP leads to dissociation of PDE4B from DISC1 and in increase in PDE4B activity.

UniProt: Q9NRI5

Pathways: Regulation of Cell Size