CXCL1 Antikörper (C-Term)

Produktnummer ABIN3030502

Produktdetails anti-CXCL1 Antikörper

Target: CXCL1 (Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, Alpha) (CXCL1))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CXCL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Antigen affinity

Immunogen: An amino acid sequence from the C-terminus of human GROA (KMLNSDKSN) was used as the immunogen for this GRO alpha antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the GRO alpha antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the GRO alpha antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu CXCL1

Target: CXCL1 (Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, Alpha) (CXCL1))

Andere Bezeichnung: GRO alpha (CXCL1 Produkte)

Synonyme: FSP antikoerper, GRO1 antikoerper, GROa antikoerper, MGSA antikoerper, MGSA-a antikoerper, NAP-3 antikoerper, SCYB1 antikoerper, CINC-1 antikoerper, Gro1 antikoerper, CXCL1 antikoerper, Sdf1 antikoerper, Fsp antikoerper, KC antikoerper, Mgsa antikoerper, N51 antikoerper, Scyb1 antikoerper, gro antikoerper, GRO antikoerper, Gro antikoerper, C-X-C motif chemokine ligand 1 antikoerper, chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) antikoerper, C-X-C motif chemokine ligand 12 antikoerper, chemokine (C-X-C motif) ligand 1 antikoerper, CXCL1 antikoerper, Cxcl1 antikoerper, Cxcl12 antikoerper, GRO1 antikoerper

Hintergrund: CXCL1 (Chemokine, CXC motif, Ligand 1), also called GRO1, SCYB1, GROA or MGSA, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO alpha, KC, Neutrophil-activating protein 3(NAP-3) and melanoma growth stimulating activity, alpha (MSGA-alpha). In humans, this protein is encoded by the CXCL1 gene. It is secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. It is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. CXCL1/GROA plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation,wound healing, and tumorigenesis. Signaling through CXCR2, CXCL1/GROA inhibited oligodendrocyte precursor migration. The migrational arrest was rapid, reversible, and concentration dependent, and it reflected enhanced cell/substrate interactions.

UniProt: P09341

Pathways: Autophagie