YBX1 Antikörper (Middle Region)

Produktnummer ABIN3029659

Produktdetails anti-YBX1 Antikörper

Target: YBX1 (Y Box Binding Protein 1 (YBX1))

Bindungsspezifität: Middle Region

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser YBX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Antigen affinity

Immunogen: An amino acid sequence from the middle region of human YBX1 (KYAADRNHYRRYPRRR) was used as the immunogen for this YB1 antibody (100% homologous in human, mouse and rat).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The stated application concentrations are suggested starting amounts. Titration of the YB1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the YB1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu YBX1

Target: YBX1 (Y Box Binding Protein 1 (YBX1))

Andere Bezeichnung: YB1 (YBX1 Produkte)

Synonyme: BP-8 antikoerper, CSDA2 antikoerper, CSDB antikoerper, DBPB antikoerper, MDR-NF1 antikoerper, NSEP-1 antikoerper, NSEP1 antikoerper, YB-1 antikoerper, YB1 antikoerper, Byb1 antikoerper, Cbfa antikoerper, Dbpb antikoerper, Ef1a antikoerper, Msy1 antikoerper, Nsep1 antikoerper, Yb1 antikoerper, bp-8 antikoerper, csda2 antikoerper, csdb antikoerper, dbpb antikoerper, frgy1 antikoerper, mdr-nf1 antikoerper, nsep-1 antikoerper, nsep1 antikoerper, yb1 antikoerper, 1700102N10Rik antikoerper, C79409 antikoerper, EF1A antikoerper, MSY1 antikoerper, dbpB antikoerper, mYB-1a antikoerper, nuclease sensitive element binding protein 1 antikoerper, Y-box binding protein 1 antikoerper, Y box binding protein 1 antikoerper, Y-box binding protein 1 S homeolog antikoerper, nuclease-sensitive element-binding protein 1 antikoerper, Y box protein 1 antikoerper, nsep1 antikoerper, YBX1 antikoerper, Ybx1 antikoerper, ybx1.S antikoerper, LOC479011 antikoerper

Hintergrund: Y box binding protein 1, commonly referred to as YBX1 or just YB1 by researchers, is a human protein. YBX1 binding has an absolute requirement for the CCAAT box and relative specificity for the Y box. It has a molecular mass of 35,414D and contains 18 % basic residues and putative nuclear localization signals. The protein is highly expressed in mouse erythroid myeloid lymphoid clone-1 (EML), a hematopoietic precursor cell line, but is downregulated in myeloid progenitors and in Gmcsf-treated EML cells during myeloid differentiation. YBX1 is expressed at high levels in myeloid leukemic cells at different developmental stages. Knockdown of the protein in a human leukemic cell line inhibited proliferation ability, induced apoptosis, and induced megakaryocytic differentiation in response to arsenic trioxide treatment. YBX1 is downregulated during myeloid differentiation and aberrant expression in leukemic cells may contribute to leukemia development by blocking differentiation.

UniProt: P67809

Pathways: Regulation of Muscle Cell Differentiation