TOX3 Antikörper (AA 200-400)
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- Target Alle TOX3 Antikörper anzeigen
- TOX3 (TOX High Mobility Group Box Family Member 3 (TOX3))
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Bindungsspezifität
- AA 200-400
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser TOX3 Antikörper ist unkonjugiert
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Applikation
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Produktmerkmale
- It recognizes an ~63 kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2+-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts.
- Aufreinigung
- Protein G affinity chromatography
- Immunogen
- A recombinant fragment (139 amino acid residues around aa 200-400) from the human protein was used as the immunogen for the TOX-3 antibody.
- Klon
- TOX3-1124
- Isotyp
- IgG1 kappa
- Top Product
- Discover our top product TOX3 Primärantikörper
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- Applikationshinweise
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Optimal dilution of the TOX-3 antibody should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Prediluted IHC only format : incubate for 30 min at RT (2)
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, *For IHC use only*
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store the TOX-3 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
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- Target
- TOX3 (TOX High Mobility Group Box Family Member 3 (TOX3))
- Andere Bezeichnung
- TOX-3 (TOX3 Produkte)
- Synonyme
- TNRC9 antikoerper, cagf9 antikoerper, tnrc9 antikoerper, CAGF9 antikoerper, 500-9 antikoerper, BC052044 antikoerper, C230068E13 antikoerper, Tnrc9 antikoerper, TOX high mobility group box family member 3 antikoerper, TOX3 antikoerper, tox3 antikoerper, Tox3 antikoerper
- Hintergrund
- It recognizes an ~63 kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2+-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts.
- Pathways
- Chromatin Binding
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