TOX3 Antikörper (AA 200-400)

Produktnummer ABIN3025030

Der Maus Monoklonal anti-TOX3 Antikörper (Klon TOX3-1123) (ABIN3025030) detektiert spezifisch TOX3 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für TOX3 Antikörper (AA 200-400) (ABIN3025030)

Target: TOX3 (TOX High Mobility Group Box Family Member 3 (TOX3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TOX3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Güteklasse: Carrier-free

Klon: TOX3-1123

Produktdetails anti-TOX3 Antikörper

Bindungsspezifität: AA 200-400

Verwendungszweck: TOX3 Antibody (azide and preservative free)

Produktmerkmale: It recognizes a 63 kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2+-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts.

Aufreinigung: Protein G affinity chromatography

Immunogen: A recombinant fragment (139 amino acid residues around aa 200-400) from the human protein was used as the immunogen for the TOX3 antibody.

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the TOX3 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store the TOX3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Details zu TOX3

Target: TOX3 (TOX High Mobility Group Box Family Member 3 (TOX3))

Andere Bezeichnung: TOX3

Hintergrund: It recognizes a 63 kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2+-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts.

UniProt: O15405

Pathways: Chromatin Binding