TAP2 Antikörper (AA 430-680)

Produktnummer ABIN3022237

Produktdetails anti-TAP2 Antikörper

Target: TAP2 (Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP2))

Bindungsspezifität: AA 430-680

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TAP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequenz: YGDMLSNVGA AEKVFSYMDR QPNLPSPGTL APTTLQGVVK FQDVSFAYPN RPDRPVLKGL TFTLRPGEVT ALVGPNGSGK STVAALLQNL YQPTGGQVLL DEKPISQYEH CYLHSQVVSV GQEPVLFSGS VRNNIAYGLQ SCEDDKVMAA AQAAHADDFI QEMEHGIYTD VGEKGSQLAA GQKQRLAIAR ALVRDPRVLI LDEATSALDV QCEQALQDWN SRGDRTVLVI AHRLQAVQRA HQILVLQEGK L

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 430-680 of human TAP2 (NP_000535.3).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze / thaw cycles

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu TAP2

Target: TAP2 (Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP2))

Andere Bezeichnung: TAP2 (TAP2 Produkte)

Synonyme: ABC18 antikoerper, ABCB3 antikoerper, APT2 antikoerper, D6S217E antikoerper, PSF-2 antikoerper, PSF2 antikoerper, RING11 antikoerper, AI462429 antikoerper, Abcb3 antikoerper, Ham-2 antikoerper, Ham2 antikoerper, MTP2 antikoerper, Tap-2 antikoerper, Y1 antikoerper, jas antikoerper, Cim antikoerper, transporter 2, ATP binding cassette subfamily B member antikoerper, transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) antikoerper, TAP2 antikoerper, Tap2 antikoerper

Hintergrund: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.,TAP2,ABC18,ABCB3,APT2,D6S217E,PSF-2,PSF2,RING11,Signal Transduction,TAP2

Molekulargewicht: 72 kDa/75 kDa

Gen-ID: 6891

UniProt: Q03519

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process