TAP2 Antikörper (AA 100-134)

Produktnummer ABIN6243497

Produktdetails anti-TAP2 Antikörper

Target: TAP2 (Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP2))

Bindungsspezifität: AA 100-134

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TAP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TAP2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 100-134 amino acids from the human region of human TAP2.

Klon: RB56970

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:2000. FC: 1:25

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu TAP2

Target: TAP2 (Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP2))

Andere Bezeichnung: TAP2 (TAP2 Produkte)

Synonyme: ABC18 antikoerper, ABCB3 antikoerper, APT2 antikoerper, D6S217E antikoerper, PSF-2 antikoerper, PSF2 antikoerper, RING11 antikoerper, AI462429 antikoerper, Abcb3 antikoerper, Ham-2 antikoerper, Ham2 antikoerper, MTP2 antikoerper, Tap-2 antikoerper, Y1 antikoerper, jas antikoerper, Cim antikoerper, transporter 2, ATP binding cassette subfamily B member antikoerper, transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) antikoerper, TAP2 antikoerper, Tap2 antikoerper

Hintergrund: Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.

Molekulargewicht: 75664

UniProt: Q03519

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process