LIM Domain Kinase 1 Antikörper (pThr508)
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- Target Alle LIM Domain Kinase 1 (LIMK1) Antikörper anzeigen
- LIM Domain Kinase 1 (LIMK1)
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Bindungsspezifität
- pThr508
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser LIM Domain Kinase 1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- Kreuzreaktivität
- Human, Maus, Ratte
- Produktmerkmale
- Phosphorylated Antibodies
- Immunogen
- A phospho specific peptide corresponding to residues surrounding T508 of human LIMK1
- Isotyp
- IgG
- Top Product
- Discover our top product LIMK1 Primärantikörper
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- Applikationshinweise
- WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:100 - 1:200
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- LIM Domain Kinase 1 (LIMK1)
- Andere Bezeichnung
- LIMK1 (LIMK1 Produkte)
- Synonyme
- limk1 antikoerper, xlimk1 antikoerper, GB16654 antikoerper, LIMK1 antikoerper, LIMK antikoerper, LIMK-1 antikoerper, LIM domain kinase 1 antikoerper, LIM domain kinase 1a antikoerper, LIM domain kinase 1 L homeolog antikoerper, LIM-domain containing, protein kinase antikoerper, LIMK1 antikoerper, limk1a antikoerper, limk1 antikoerper, CpipJ_CPIJ000717 antikoerper, LOC413152 antikoerper, Limk1 antikoerper, limk1.L antikoerper
- Hintergrund
- There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.,LIMK1,LIMK,LIMK-1,Signal Transduction,Kinase,Serine/threonine kinases,Tyrosine kinases,Cell Biology & Developmental Biology,Cytoskeleton,Microfilaments,Microtubules,Actins,TGF-b-Smad Signaling Pathway,Immunology & Inflammation,Neuroscience,Cell Type Marker,Neuron marker,Growth Cone,Protein phosphorylation,LIMK1
- Molekulargewicht
- 33 kDa/68 kDa/70 kDa/72 kDa
- Gen-ID
- 3984
- UniProt
- P53667
- Pathways
- Caspase Kaskade in der Apoptose, Regulation of Cell Size, CXCR4-mediated Signaling Events
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