ADAMTS5 Antikörper (AA 731-930)

Produktnummer ABIN3016806

Produktdetails anti-ADAMTS5 Antikörper

Target: ADAMTS5 (ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5))

Bindungsspezifität: AA 731-930

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ADAMTS5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 731-930 of human ADAMTS5 (NP_008969.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-ADAMTS5 Antikörper (ABIN3016806)

Si, Zeng, Liu, Zhou, Chen, Cheng, Lu, Shen: "Intra-articular injection of microRNA-140 (miRNA-140) alleviates osteoarthritis (OA) progression by modulating extracellular matrix (ECM) homeostasis in rats." in: Osteoarthritis and cartilage, Vol. 25, Issue 10, pp. 1698-1707, (2018) (PubMed).

Details zu ADAMTS5

Target: ADAMTS5 (ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5))

Andere Bezeichnung: ADAMTS5 (ADAMTS5 Produkte)

Synonyme: 9530092O11Rik antikoerper, ADAM-TS5 antikoerper, ADAMTS1 antikoerper, ADAMTS11 antikoerper, AI481094 antikoerper, ASMP-2 antikoerper, ADAM-TS 11 antikoerper, ADAM-TS 5 antikoerper, ADAMTS-11 antikoerper, ADAMTS-5 antikoerper, ADMP-2 antikoerper, ADAM metallopeptidase with thrombospondin type 1 motif 5 antikoerper, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) antikoerper, ADAM metallopeptidase with thrombospondin type 1 motif, 5 antikoerper, ADAMTS5 antikoerper, adamts5 antikoerper, Adamts5 antikoerper

Hintergrund: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis.,ADAMTS5,ADAM-TS 11,ADAM-TS 5,ADAM-TS5,ADAMTS-11,ADAMTS-5,ADAMTS11,ADMP-2,ADAM-TS11,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Extracellular Matrix,ADAM Protein Family,MMPs,Ubiquitin,ADAMTS5

Molekulargewicht: 101 kDa

Gen-ID: 11096

UniProt: Q9UNA0