RANKL Antikörper (C-Term)
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- Target Alle RANKL (TNFSF11) Antikörper anzeigen
- RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))
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Bindungsspezifität
- C-Term
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Reaktivität
- Human, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser RANKL Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Kreuzreaktivität
- Rind (Kuh), Huhn, Maus
- Kreuzreaktivität (Details)
- Mouse (93 %), Chicken (87 %), Bovine (100 %)
- Produktmerkmale
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Rabbit Polyclonal antibody to RANKL (tumor necrosis factor (ligand) superfamily, member 11)
RANKL antibody [C2C3], C-term - Aufreinigung
- Purified by antigen-affinity chromatography.
- Immunogen
- Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human RANKL. The exact sequence is proprietary.
- Isotyp
- IgG
- Top Product
- Discover our top product TNFSF11 Primärantikörper
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- Applikationshinweise
- Suggested dilution Reference IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceIHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*
- Kommentare
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Positive Control: A431 , H1299 , HeLa , HepG2 , Rat lung
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.
- Konservierungsmittel
- Thimerosal (Merthiolate)
- Vorsichtsmaßnahmen
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- Target
- RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))
- Andere Bezeichnung
- RANKL (TNFSF11 Produkte)
- Synonyme
- CD254 antikoerper, ODF antikoerper, OPGL antikoerper, OPTB2 antikoerper, RANKL antikoerper, TRANCE antikoerper, hRANKL2 antikoerper, sOdf antikoerper, TNFSF11 antikoerper, Ly109l antikoerper, OPG antikoerper, Trance antikoerper, cd254 antikoerper, odf antikoerper, opgl antikoerper, optb2 antikoerper, rankl antikoerper, sodf antikoerper, tnfsf11 antikoerper, trance antikoerper, TNF superfamily member 11 antikoerper, tumor necrosis factor (ligand) superfamily, member 11 antikoerper, TNF receptor superfamily member 11b antikoerper, TNF superfamily member 11 L homeolog antikoerper, TNFSF11 antikoerper, Tnfsf11 antikoerper, TNFRSF11B antikoerper, tnfsf11.L antikoerper
- Hintergrund
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This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
Cellular Localization: Isoform 1: Cell membrane, Single-pass type II membrane protein , Isoform 3: Cell membrane, Single-pass type II membrane protein , Isoform 2: Cytoplasm , Tumor necrosis factor ligand superfamily member 11 , soluble form: Secreted - Molekulargewicht
- 35 kDa
- Gen-ID
- 8600
- Pathways
- NF-kappaB Signalweg
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