NR4A2 Antikörper (N-Term)
-
- Target Alle NR4A2 Antikörper anzeigen
- NR4A2 (Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2))
-
Bindungsspezifität
- AA 13-42, N-Term
-
Reaktivität
- Maus
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser NR4A2 Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Homologie
- B, Rat
- Aufreinigung
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Immunogen
- This NURR1 (NR4A2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-42 amino acids from the N-terminal region of human NURR1 (NR4A2).
- Klon
- RB7385
- Isotyp
- Ig Fraction
- Top Product
- Discover our top product NR4A2 Primärantikörper
-
-
- Applikationshinweise
- IF: 1:10~50. WB: 1:1000. IHC-P: 1:50~100
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- Haltbarkeit
- 6 months
-
-
Schizophrenia-like features in transgenic mice overexpressing human HO-1 in the astrocytic compartment." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 32, pp. 10841-53, (2012) (PubMed).
: "
-
Schizophrenia-like features in transgenic mice overexpressing human HO-1 in the astrocytic compartment." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 32, pp. 10841-53, (2012) (PubMed).
-
- Target
- NR4A2 (Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2))
- Andere Bezeichnung
- NURR1 (NR4A2) (NR4A2 Produkte)
- Synonyme
- nr41/42/43 antikoerper, Nr4a2 antikoerper, nurr1 antikoerper, not antikoerper, rnr1 antikoerper, hzf-3 antikoerper, tinur antikoerper, NGFI-B antikoerper, HZF-3 antikoerper, NOT antikoerper, NURR1 antikoerper, RNR1 antikoerper, TINUR antikoerper, Nurr1 antikoerper, RNR-1 antikoerper, TINOR antikoerper, ngf1b antikoerper, nr4a2 antikoerper, zgc:92696 antikoerper, nuclear receptor subfamily 4 group A member 2 antikoerper, nuclear receptor antikoerper, nuclear receptor subfamily 4, group A, member 2 antikoerper, nuclear receptor subfamily 4, group A, member 2b antikoerper, NR4A2 antikoerper, nr41/42/43 antikoerper, nr4a2 antikoerper, Nr4a2 antikoerper, nr4a2b antikoerper
- Hintergrund
- Parkinson's disease (PD) is a multifactorial disease that appears to arise from the effects of both genetic and environmental influences. The known genetic factors include multiple genes that have been identified in related parkinsonian syndromes, as well as alpha-synuclein. Genes associated with either PD or Parkinson-related disorders include parkin, DJ-1, ubiquitin C-terminal hydrolase isozyme L1 (UCH-L1), nuclear receptor-related factor 1 (NURR1), and alpha-synuclein. Nurr1 is a transcription factor that is expressed in the embryonic ventral midbrain and is critical for the development of dopamine (DA) neurons. It belongs to the conserved family of nuclear receptors but lacks an identified ligand and is therefore referred to as an orphan receptor. RXR ligands can promote the survival of DA neurons via a process that depends on Nurr1-RXR heterodimers. In developing DA cells, Nurr1 is required for the expression of several genes important for DA synthesis and function. Nurr1 is also important for the maintenance of adult DA neurons.
- Molekulargewicht
- 66591
- Gen-ID
- 4929
- NCBI Accession
- NP_006177
- UniProt
- P43354
- Pathways
- Nuclear Receptor Transcription Pathway, Dopaminergic Neurogenesis, Steroid Hormone Mediated Signaling Pathway
-