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NR4A2 Antikörper (AA 13-42)

NR4A2 Reaktivität: Human, Maus WB, ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3032065
  • Target Alle NR4A2 Antikörper anzeigen
    NR4A2 (Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2))
    Bindungsspezifität
    • 15
    • 15
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 13-42
    Reaktivität
    • 60
    • 45
    • 41
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus
    Wirt
    • 61
    • 3
    Kaninchen
    Klonalität
    • 61
    • 3
    Polyklonal
    Konjugat
    • 34
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser NR4A2 Antikörper ist unkonjugiert
    Applikation
    • 61
    • 26
    • 26
    • 16
    • 13
    • 12
    • 8
    • 7
    • 5
    • 4
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    Kreuzreaktivität (Details)
    Expected species reactivity: Rat, Bovine
    Aufreinigung
    Purified
    Immunogen
    A portion of amino acids 13-42 from the human protein was used as the immunogen for this NURR1 antibody.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product NR4A2 Primärantikörper
  • Applikationshinweise
    Titration of the NURR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100,Immunofluorescence: 1:10-1:50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Aliquot the NURR1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    NR4A2 (Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2))
    Andere Bezeichnung
    NURR1 (NR4A2 Produkte)
    Synonyme
    nr41/42/43 antikoerper, Nr4a2 antikoerper, nurr1 antikoerper, not antikoerper, rnr1 antikoerper, hzf-3 antikoerper, tinur antikoerper, NGFI-B antikoerper, HZF-3 antikoerper, NOT antikoerper, NURR1 antikoerper, RNR1 antikoerper, TINUR antikoerper, Nurr1 antikoerper, RNR-1 antikoerper, TINOR antikoerper, ngf1b antikoerper, nr4a2 antikoerper, zgc:92696 antikoerper, nuclear receptor subfamily 4 group A member 2 antikoerper, nuclear receptor antikoerper, nuclear receptor subfamily 4, group A, member 2 antikoerper, nuclear receptor subfamily 4, group A, member 2b antikoerper, NR4A2 antikoerper, nr41/42/43 antikoerper, nr4a2 antikoerper, Nr4a2 antikoerper, nr4a2b antikoerper
    Hintergrund
    Parkinson's disease (PD) is a multifactorial disease that appears to arise from the effects of both genetic and environmental influences. The known genetic factors include multiple genes that have been identified in related parkinsonian syndromes, as well as alpha-synuclein. Genes associated with either PD or Parkinson-related disorders include parkin, DJ-1, ubiquitin C-terminal hydrolase isozyme L1 (UCH-L1), nuclear receptor-related factor 1 (NURR1), and alpha-synuclein. Nurr1 is a transcription factor that is expressed in the embryonic ventral midbrain and is critical for the development of dopamine (DA) neurons. It belongs to the conserved family of nuclear receptors but lacks an identified ligand and is therefore referred to as an orphan receptor. RXR ligands can promote the survival of DA neurons via a process that depends on Nurr1-RXR heterodimers. In developing DA cells, Nurr1 is required for the expression of several genes important for DA synthesis and function. Nurr1 is also important for the maintenance of adult DA neurons.
    UniProt
    P43354
    Pathways
    Nuclear Receptor Transcription Pathway, Dopaminergic Neurogenesis, Steroid Hormone Mediated Signaling Pathway
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