NR4A2 Antikörper (AA 13-42)
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- Target Alle NR4A2 Antikörper anzeigen
- NR4A2 (Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2))
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Bindungsspezifität
- AA 13-42
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser NR4A2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Kreuzreaktivität (Details)
- Expected species reactivity: Rat, Bovine
- Aufreinigung
- Purified
- Immunogen
- A portion of amino acids 13-42 from the human protein was used as the immunogen for this NURR1 antibody.
- Isotyp
- Ig Fraction
- Top Product
- Discover our top product NR4A2 Primärantikörper
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- Applikationshinweise
- Titration of the NURR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100,Immunofluorescence: 1:10-1:50
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Aliquot the NURR1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- Target
- NR4A2 (Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2))
- Andere Bezeichnung
- NURR1 (NR4A2 Produkte)
- Synonyme
- nr41/42/43 antikoerper, Nr4a2 antikoerper, nurr1 antikoerper, not antikoerper, rnr1 antikoerper, hzf-3 antikoerper, tinur antikoerper, NGFI-B antikoerper, HZF-3 antikoerper, NOT antikoerper, NURR1 antikoerper, RNR1 antikoerper, TINUR antikoerper, Nurr1 antikoerper, RNR-1 antikoerper, TINOR antikoerper, ngf1b antikoerper, nr4a2 antikoerper, zgc:92696 antikoerper, nuclear receptor subfamily 4 group A member 2 antikoerper, nuclear receptor antikoerper, nuclear receptor subfamily 4, group A, member 2 antikoerper, nuclear receptor subfamily 4, group A, member 2b antikoerper, NR4A2 antikoerper, nr41/42/43 antikoerper, nr4a2 antikoerper, Nr4a2 antikoerper, nr4a2b antikoerper
- Hintergrund
- Parkinson's disease (PD) is a multifactorial disease that appears to arise from the effects of both genetic and environmental influences. The known genetic factors include multiple genes that have been identified in related parkinsonian syndromes, as well as alpha-synuclein. Genes associated with either PD or Parkinson-related disorders include parkin, DJ-1, ubiquitin C-terminal hydrolase isozyme L1 (UCH-L1), nuclear receptor-related factor 1 (NURR1), and alpha-synuclein. Nurr1 is a transcription factor that is expressed in the embryonic ventral midbrain and is critical for the development of dopamine (DA) neurons. It belongs to the conserved family of nuclear receptors but lacks an identified ligand and is therefore referred to as an orphan receptor. RXR ligands can promote the survival of DA neurons via a process that depends on Nurr1-RXR heterodimers. In developing DA cells, Nurr1 is required for the expression of several genes important for DA synthesis and function. Nurr1 is also important for the maintenance of adult DA neurons.
- UniProt
- P43354
- Pathways
- Nuclear Receptor Transcription Pathway, Dopaminergic Neurogenesis, Steroid Hormone Mediated Signaling Pathway
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