Activin A Receptor Type IB/ALK-4 Antikörper (AA 51-150) (Alexa Fluor 594)
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- Target Alle Activin A Receptor Type IB/ALK-4 (ACVR1B) Antikörper anzeigen
- Activin A Receptor Type IB/ALK-4 (ACVR1B) (Activin A Receptor, Type IB (ACVR1B))
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Bindungsspezifität
- AA 51-150
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Reaktivität
- Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Activin A Receptor Type IB/ALK-4 Antikörper ist konjugiert mit Alexa Fluor 594
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Applikation
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Kreuzreaktivität
- Ratte
- Homologie
- Human,Mouse,Dog,Cow,Pig,Horse,Rabbit
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human ACVR1B
- Isotyp
- IgG
- Top Product
- Discover our top product ACVR1B Primärantikörper
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- Applikationshinweise
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- Activin A Receptor Type IB/ALK-4 (ACVR1B) (Activin A Receptor, Type IB (ACVR1B))
- Andere Bezeichnung
- ACVR1B (ACVR1B Produkte)
- Synonyme
- ACVR1B antikoerper, alk4 antikoerper, skr2 antikoerper, alk-4 antikoerper, xalk4 antikoerper, actrib antikoerper, acvrlk4 antikoerper, DKFZp469A1614 antikoerper, 6820432J04 antikoerper, ActR-IB antikoerper, ActRIB antikoerper, Acvrlk4 antikoerper, Alk4 antikoerper, SKR2 antikoerper, ACTRIB antikoerper, ACVRLK4 antikoerper, ALK4 antikoerper, Skr2 antikoerper, axis antikoerper, taram-a antikoerper, tarama antikoerper, wu:fb75f01 antikoerper, activin A receptor type 1B antikoerper, Activin receptor type-1B antikoerper, activin A receptor, type IB antikoerper, activin A receptor, type 1B antikoerper, activin A receptor type 1Ba antikoerper, ACVR1B antikoerper, acvr1b antikoerper, acv1b antikoerper, Acvr1b antikoerper, acvr1ba antikoerper
- Hintergrund
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Synonyms: ALK4, SKR2, ACTRIB, ACVRLK4, Activin receptor type-1B, Activin receptor type IB, ACTR-IB, Activin receptor-like kinase 4, ALK-4, Serine/threonine-protein kinase receptor R2, ACVR1B
Background: Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.
- Gen-ID
- 91
- UniProt
- P36896
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