TWIST1, TWIST2 (AA 71-170) Antikörper (Alexa Fluor 594)

Produktnummer ABIN2807311

Produktdetails

Target: TWIST1, TWIST2

Bindungsspezifität: AA 71-170

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Alexa Fluor 594

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Western Blotting (WB)

Spezifität: This antibody will detect TWIST1 and TWIST2

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TWIST1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: TWIST1, TWIST2

Andere Bezeichnung: TWIST1 and TWIST2

Synonyme: Twist antikoerper, DERMO1 antikoerper, FFDD3 antikoerper, SETLSS antikoerper, bHLHa39 antikoerper, AA960487 antikoerper, M-Twist antikoerper, Pde antikoerper, Ska10 antikoerper, Ska antikoerper, bHLHa38 antikoerper, pdt antikoerper, FDXP2 antikoerper, twist family bHLH transcription factor 1 antikoerper, twist family bHLH transcription factor 2 antikoerper, twist basic helix-loop-helix transcription factor 1 antikoerper, ferredoxin 1 pseudogene 2 antikoerper, Twist1 antikoerper, TWIST2 antikoerper, FDX1P2 antikoerper

Hintergrund:

Synonyms: TWIST, bHLHa38, Twist-related protein 1, Class A basic helix-loop-helix protein 38, H-twist, TWIST1, bHLHa39, Class A basic helix-loop-helix protein 39, Dermis expressed protein 1, Dermis-expressed protein 1, DERMO 1, Dermo-1, DERMO1, MGC117334, Twist 2, Twist homolog 2 Drosophila, Twist homolog 2, Twist related bHLH protein Dermo1, Twist related protein 2, Twist-related protein 2, Twist2, TWST2_HUMAN.

Background: TWIST1 and TWIST2 are basic helix-loop-helix transcriptional repressors that bind to E boxes in gene promoters, acting as master regulators in a variety of biological processes, including organogenesis, osteogenesis, cancer progression and hematopoietic cell development. Both TWIST1 and TWIST2 are found to act as Homodimers or Heterodimers with another bHLH protein. TWIST1 Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. TWIST1 also represses expression of proinflammatory cytokines such as TNFA and IL1B. TWIST2 inhibits transcriptional activation by MYOD1, MYOG, MEF2A, and MEF2C. Twist2 inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis.

Gen-ID: 7291, 117581

UniProt: Q15672, Q8WVJ9