TWIST1, TWIST2 (AA 71-170) Antikörper
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- Target
- TWIST1, TWIST2
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Bindungsspezifität
- AA 71-170
- Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Unkonjugiert
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Applikation
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro))
- Spezifität
- This antibody will detect TWIST1 and TWIST2
- Kreuzreaktivität
- Human, Maus, Ratte
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human TWIST1
- Isotyp
- IgG
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- Applikationshinweise
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- TWIST1, TWIST2
- Andere Bezeichnung
- TWIST1 and TWIST2
- Synonyme
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Twist antikoerper, DERMO1 antikoerper, FFDD3 antikoerper, SETLSS antikoerper, bHLHa39 antikoerper, AA960487 antikoerper, M-Twist antikoerper, Pde antikoerper, Ska10 antikoerper, Ska
antikoerper, bHLHa38 antikoerper, pdt antikoerper, FDXP2 antikoerper, twist family bHLH transcription factor 1 antikoerper, twist family bHLH transcription factor 2 antikoerper, twist basic helix-loop-helix transcription factor 1 antikoerper, ferredoxin 1 pseudogene 2 antikoerper, Twist1 antikoerper, TWIST2 antikoerper, FDX1P2 antikoerper - Hintergrund
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Synonyms: TWIST, bHLHa38, Twist-related protein 1, Class A basic helix-loop-helix protein 38, H-twist, TWIST1, bHLHa39, Class A basic helix-loop-helix protein 39, Dermis expressed protein 1, Dermis-expressed protein 1, DERMO 1, Dermo-1, DERMO1, MGC117334, Twist 2, Twist homolog 2 Drosophila, Twist homolog 2, Twist related bHLH protein Dermo1, Twist related protein 2, Twist-related protein 2, Twist2, TWST2_HUMAN.
Background: TWIST1 and TWIST2 are basic helix-loop-helix transcriptional repressors that bind to E boxes in gene promoters, acting as master regulators in a variety of biological processes, including organogenesis, osteogenesis, cancer progression and hematopoietic cell development. Both TWIST1 and TWIST2 are found to act as Homodimers or Heterodimers with another bHLH protein. TWIST1 Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. TWIST1 also represses expression of proinflammatory cytokines such as TNFA and IL1B. TWIST2 inhibits transcriptional activation by MYOD1, MYOG, MEF2A, and MEF2C. Twist2 inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis.
- Gen-ID
- 7291, 117581
- UniProt
- Q15672, Q8WVJ9
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