Neuregulin 1 Antikörper (AA 241-340) (Alexa Fluor 594)

Produktnummer ABIN2805582

Produktdetails anti-Neuregulin 1 Antikörper (Alexa Fluor 594)

Target: Neuregulin 1 (NRG1)

Bindungsspezifität: AA 241-340

Reaktivität: Human, Ratte, Maus, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Neuregulin 1 Antikörper ist konjugiert mit Alexa Fluor 594

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Maus, Ratte, Zebrafisch (Danio rerio)

Homologie: Dog,Pig,Horse,Chicken,Rabbit,Guinea Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Pro-Neuregulin 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Neuregulin 1

Target: Neuregulin 1 (NRG1)

Andere Bezeichnung: Pro-Neuregulin 1 (NRG1 Produkte)

Synonyme: 6030402G23Rik antikoerper, ARIA antikoerper, D230005F13Rik antikoerper, GGF antikoerper, GGFII antikoerper, HRG antikoerper, HRGalpha antikoerper, Hgl antikoerper, NDF antikoerper, SMDF antikoerper, GGF2 antikoerper, HGL antikoerper, HRG1 antikoerper, HRGA antikoerper, MST131 antikoerper, NRG-1 antikoerper, heregulin antikoerper, nrg1-A antikoerper, pro-neuregulin-1 antikoerper, NRG1 antikoerper, wu:fm70e01 antikoerper, DKFZp459A1838 antikoerper, neuregulin 1 antikoerper, histidine rich glycoprotein antikoerper, neuregulin 1 L homeolog antikoerper, Nrg1 antikoerper, NRG1 antikoerper, HRG antikoerper, nrg1.L antikoerper, nrg1 antikoerper

Hintergrund:

Synonyms: GGF, HGL, HRG, NDF, ARIA, GGF2, HRG1, HRGA, SMDF, MST131, MSTP131, NRG1-IT2, Pro-neuregulin-1, membrane-bound isoform, Pro-NRG1, NRG1

Background: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells, inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction, stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells, stimulating Schwann cell proliferation, implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.

Gen-ID: 3084

UniProt: Q02297

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Muscle Cell Differentiation