PKMYT1 Antikörper (AA 121-220) (Alexa Fluor 594)

Produktnummer ABIN2805392

Produktdetails anti-PKMYT1 Antikörper (Alexa Fluor 594)

Target: PKMYT1 (Protein Kinase, Membrane Associated tyrosine/threonine 1 (PKMYT1))

Bindungsspezifität: AA 121-220

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PKMYT1 Antikörper ist konjugiert mit Alexa Fluor 594

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Mouse,Rat,Dog,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PKMYT1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu PKMYT1

Target: PKMYT1 (Protein Kinase, Membrane Associated tyrosine/threonine 1 (PKMYT1))

Andere Bezeichnung: PKMYT1 (PKMYT1 Produkte)

Synonyme: MYT1 antikoerper, 6230424P17 antikoerper, AW209059 antikoerper, Myt1 antikoerper, RGD1305434 antikoerper, myt1 antikoerper, protein kinase, membrane associated tyrosine/threonine 1 antikoerper, protein kinase, membrane associated tyrosine/threonine 1 S homeolog antikoerper, PKMYT1 antikoerper, pkmyt1 antikoerper, Pkmyt1 antikoerper, pkmyt1.S antikoerper

Hintergrund:

Synonyms: cdc2 inhibitory kinase, Membrane associated tyrosine and threonine specic cdc2 inhibitory kinase, Membrane-associated tyrosine- and threonine-specic cdc2-inhibitory kinase, MYT1, Myt1 kinase, PKMYT 1, Pkmyt1, PMYT1_HUMAN, Protein kinase membrane associated tyrosine/threonine 1, Protein kinase Myt1, DKFZp547K1610, FLJ20093.

Background: PKMYT1 is a member of the serine/threonine protein kinase family. It preferentially phosphorylates and inactivates cell division cycle 2 protein (cdc2), and thus acts as a negative regulator of entry into mitosis (G2 to M transition). It mediates phosphorylation of cdc2 predominantly on 'Thr-14' and is also involved in Golgi fragmentation. It may be involved in phosphorylation of cdc2 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. It may be a downstream target of Notch signaling pathway during eye development. PKMYT1 is negatively regulated by hyperphosphorylation during mitosis.

Gen-ID: 9088

Pathways: Mitotic G1-G1/S Phases, M Phase