BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 9-37), (N-Term) Antikörper

Produktnummer ABIN2793437

Produktdetails

Target: BRISC and BRCA1 A Complex Member 1 (BABAM1)

Bindungsspezifität: AA 9-37, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Verwendungszweck: Rabbit Anti-Human HSPC142 (N-term) Antibody

Immunogen: This HSPC142 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-37 amino acids from the N-terminal region of human HSPC142.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Western Blot, Immunohistochemistry
Recommended Dilutions
WB: 1:1000, IHC: 1:50-100HSPC142 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 2-8°C (short-term), -20°C (long-term)

Antigendetails

Target: BRISC and BRCA1 A Complex Member 1 (BABAM1)

Andere Bezeichnung: HSPC142 (BABAM1 Produkte)

Synonyme: merit40 antikoerper, nba1 antikoerper, zgc:100909 antikoerper, c19orf62 antikoerper, C19orf62 antikoerper, MERIT40 antikoerper, NBA1 antikoerper, C7H19orf62 antikoerper, 5430437P03Rik antikoerper, Merit40 antikoerper, BRISC and BRCA1 A complex member 1 antikoerper, BRISC and BRCA1 A complex member 1 L homeolog antikoerper, babam1 antikoerper, BABAM1 antikoerper, babam1.L antikoerper, Babam1 antikoerper

Hintergrund:

Target Description: HSPC142 is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. HSPC142 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36. component

Gene Symbol: BABAM1

Molekulargewicht: 36560 Da

Gen-ID: 29086

UniProt: Q9NWV8

Pathways: Positive Regulation of Response to DNA Damage Stimulus