DOK2 Antikörper (C-Term)

Produktnummer ABIN184203

Produktdetails anti-DOK2 Antikörper

Target: DOK2

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Schwein, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DOK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: QEPRGEAWRR QATRDRDPAG LQHVQPAGQD FSASGWQPGT EYDNVVLKKG

Homologie: Cow: 100%, Dog: 90%, Horse: 90%, Human: 100%, Mouse: 90%, Pig: 100%, Rat: 90%

Produktmerkmale: This is a rabbit polyclonal antibody against DOK2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human DOK2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 412 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu DOK2

Target: DOK2

Andere Bezeichnung: DOK2 (DOK2 Produkte)

Synonyme: DokR antikoerper, Frip antikoerper, Dok-2 antikoerper, p56DOK antikoerper, p56dok-2 antikoerper, docking protein 2 antikoerper, DOK2 antikoerper, Dok2 antikoerper

Hintergrund: DOK2 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr/abl), a chimeric protein whose presence is associated with CML. DOK2 binds p120 (RasGAP) from CML cells.The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.
Alias Symbols: p56DOK, p56dok-2
Protein Interaction Partner: UBC, RASA1, ABL1, POT1, EGFR, KIAA1279, INPP5D, NCK1, TEK, SRC, LYN, RET, LCK, IL4R, HCK, HSPA4L, ASF1B, DNAJB11, RAB10, SSSCA1, CFLAR, SPOP, SHC1, PSMD10, DOK1,
Protein Size: 412

Molekulargewicht: 45 kDa

Gen-ID: 9046

NCBI Accession: NM_003974, NP_003965

UniProt: O60496