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DOK2 Antikörper (C-Term)

DOK2 Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB1757 unconjugated
Produktnummer ABIN392072
  • Target Alle DOK2 Antikörper anzeigen
    DOK2
    Bindungsspezifität
    • 26
    • 22
    • 15
    • 10
    • 7
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 380-412, C-Term
    Reaktivität
    • 120
    • 79
    • 18
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    Human
    Wirt
    • 131
    • 4
    Kaninchen
    Klonalität
    • 131
    • 4
    Polyklonal
    Konjugat
    • 43
    • 9
    • 7
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    Dieser DOK2 Antikörper ist unkonjugiert
    Applikation
    • 101
    • 52
    • 52
    • 41
    • 27
    • 19
    • 12
    • 12
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This DOK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 380-412 amino acids from the C-terminal region of human DOK2.
    Klon
    RB1757
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product DOK2 Primärantikörper
  • Applikationshinweise
    WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Target
    DOK2
    Andere Bezeichnung
    DOK2 (DOK2 Produkte)
    Synonyme
    DokR antikoerper, Frip antikoerper, Dok-2 antikoerper, p56DOK antikoerper, p56dok-2 antikoerper, docking protein 2 antikoerper, DOK2 antikoerper, Dok2 antikoerper
    Hintergrund
    Docking proteins interact with receptor tyrosine kinases and mediate particular biological responses using signal transduction. Dok-2 acts as a multiple docking protein downstream of receptor or non-receptor tyrosine kinases. By this mechanism it acts to negatively regulate signal transduction and cell proliferation controlled by cytokines in a feedback loop. Dok-2 is highly expressed in cells and tissues of hematopoietic origin as well as in lung. Expression of bcr/abl induces additional tyrosine phosphorylation of the Dok1 and Dok2 proteins and their association with Ras-GAP. Thus, it is suspected that DOK association regulates GAP activity toward Ras and that the Dok proteins serve as mediators of bcr-abl signaling. The role of Dok proteins in bcr-abl regulation may also be implicated in chronic myelogenous leukemia (CML), which is characterized by a Philadelphia chromosome translocation t(9,22). Such a mutation would result in a p210-bcr/abl chimeric protein-tyrosine kinase which has been found in many CML cases.
    Molekulargewicht
    45379
    Gen-ID
    9046
    NCBI Accession
    NP_003965
    UniProt
    O60496
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