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PRNP Antikörper (Middle Region)
PRNP
Reaktivität: Human, Ratte, Rind (Kuh), Schaf, Hund, Ziege
WB, IHC
Wirt: Kaninchen
Polyclonal
unconjugated
Produktnummer ABIN2499236
Produktdetails anti-PRNP Antikörper
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Target
Alle PRNP Antikörper anzeigen
PRNP
(Prion Protein (PRNP))
Bindungsspezifität
Alle Epitope für PRNP Antikörper
Middle Region
Reaktivität
Alle Reaktivitäten für PRNP Antikörper
Human, Ratte, Rind (Kuh), Schaf, Hund, Ziege
Wirt
Alle Wirte für PRNP Antikörper
Kaninchen
Klonalität
Alle Klonalitäten für PRNP Antikörper
Polyklonal
Konjugat
Alle Konjugate für PRNP Antikörper
Dieser PRNP Antikörper ist unkonjugiert
Applikation
Alle Applikationen für PRNP Antikörper
Western Blotting (WB), Immunohistochemistry (IHC)
Sequenz
GGGTHNQWNK PSKPKTNLKH VAGAAAAGAV VGGLGGYMLG SAMSRPMIHF
Homologie
Cow: 100%, Dog: 100%, Goat: 100%, Human: 100%, Rat: 100%, Sheep: 100%
Produktmerkmale
This is a rabbit polyclonal antibody against Prnp. It was validated on Western Blot.
Aufreinigung
Affinity Purified
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of Mouse Prnp
Top Product
Discover our top product PRNP Primärantikörper
Alternativen
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Anwendungsinformationen
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Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Konzentration
1 mg/mL
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeat freeze-thaw cycles.
Lagerung
-20 °C
Informationen zur Lagerung
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Details zu PRNP
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Target
PRNP
(Prion Protein (PRNP))
Andere Bezeichnung
Prnp (PRNP Produkte )
Synonyme
ASCR antikoerper, AltPrP antikoerper, CD230 antikoerper, CJD antikoerper, GSS antikoerper, KURU antikoerper, PRIP antikoerper, PrP antikoerper, PrP27-30 antikoerper, PrP33-35C antikoerper, PrPc antikoerper, p27-30 antikoerper, Prn antikoerper, Prn-p antikoerper, prp antikoerper, cjd antikoerper, prion antikoerper, prp(c) antikoerper, MGC84114 antikoerper, PRP antikoerper, PRPC antikoerper, Prp antikoerper, SIP antikoerper, PRNP antikoerper, AA960666 antikoerper, AI325101 antikoerper, PrP antikoerper, PrPC antikoerper, PrPSc antikoerper, Prn-i antikoerper, Sinc antikoerper, prP27-30 antikoerper, prP33-35C antikoerper, PrP-1 antikoerper, PrP1 antikoerper, prnprs1 antikoerper, stPrP-1 antikoerper, zgc:123004 antikoerper, prion protein antikoerper, prion protein S homeolog antikoerper, prion protein b antikoerper, PRNP antikoerper, Prnp antikoerper, prnp.S antikoerper, prnpb antikoerper
Hintergrund
Prnp may play a role in neuronal development and synaptic plasticity, may be required for neuronal myelin sheath maintenance and may play a role in iron uptake and iron homeostasis. Prnp is a soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. It also provides Cu2+ or ZN2+ for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains. Alias Symbols: AA960666, AI325101, CD230, PrP, PrP, PrPC, PrPSc, Prn-i, Prn-p, Sinc, prP27-30, prP33-35C Protein Interaction Partner: Dpp6, Eri3, Syn1, Grb2, Opcml, Lsamp, Ntm, Atp1a3, Igsf8, Cadm3, Clstn1, Pde10a, Adam23, Ywhaz, Ywhae, Stxbp1, Plp1, P4hb, Ncam2, Ncam1, Mog, Mbp, Mag, L1cam, Hspa5, Gnb1, Sparcl1, Dnm1, Dpysl2, Cntn1, Clu, Atp2b2, Atp1b1, Atp1a1, App, Apoe, Aplp2, Apbb1, Protein Size: 254
Molekulargewicht
28 kDa
Gen-ID
19122
NCBI Accession
NM_011170 , NP_035300
UniProt
P04925
Pathways
Transition Metal Ion Homeostasis , Activated T Cell Proliferation
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