HLA-DMA Antikörper (N-Term)

Produktnummer ABIN2788737

Produktdetails anti-HLA-DMA Antikörper

Target: HLA-DMA (Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA))

Bindungsspezifität: N-Term

Reaktivität: Human, Ratte, Kaninchen, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HLA-DMA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: GLSEAYDEDQ LFFFDFSQNT RVPRLPEFAD WAQEQGDAPA ILFDKEFCEW

Homologie: Dog: 77%, Human: 100%, Rabbit: 82%, Rat: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against HLA-DMA. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HLA-DMA

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 261 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu HLA-DMA

Target: HLA-DMA (Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA))

Andere Bezeichnung: HLA-DMA (HLA-DMA Produkte)

Synonyme: RT1.Ma antikoerper, RT1.DMa antikoerper, HLA-DMA antikoerper, H-2Ma antikoerper, H2-Ma antikoerper, D6S222E antikoerper, DMA antikoerper, HLADM antikoerper, RING6 antikoerper, RT1 class II, locus DMa antikoerper, SLA-DM alpha chain antikoerper, major histocompatibility complex, class II, DM alpha antikoerper, histocompatibility 2, class II, locus DMa antikoerper, RT1-DMa antikoerper, SLA-DMA antikoerper, DLA-DMA antikoerper, H2-DMa antikoerper, HLA-DMA antikoerper

Hintergrund: HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.
Alias Symbols: D6S222E, DMA, HLADM, RING6
Protein Interaction Partner: B3GAT1, U2AF2, RUNX1, UBC, CD82, HLA-DRB1, HLA-DOA, HLA-DRA, HLA-DMB, CD74,
Protein Size: 261

Molekulargewicht: 29 kDa

Gen-ID: 3108

NCBI Accession: NM_006120, NP_006111

UniProt: Q31604

Pathways: Cancer Immune Checkpoints