PCSK1N Antikörper (N-Term)
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- Target Alle PCSK1N Antikörper anzeigen
- PCSK1N (Proprotein Convertase Subtilisin/kexin Type 1 Inhibitor (PCSK1N))
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Bindungsspezifität
- N-Term
- Reaktivität
- Human, Maus, Ratte, Meerschweinchen, Rind (Kuh), Hund
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser PCSK1N Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- STPLRLRRAV PRGEAAGAVQ ELARALAHLL EAERQERARA EAQEAEDQQA
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rat: 100%
- Produktmerkmale
- This is a rabbit polyclonal antibody against Pcsk1n. It was validated on Western Blot.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N-terminal region of Rat Pcsk1n
- Top Product
- Discover our top product PCSK1N Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 260 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- PCSK1N (Proprotein Convertase Subtilisin/kexin Type 1 Inhibitor (PCSK1N))
- Andere Bezeichnung
- Pcsk1n (PCSK1N Produkte)
- Synonyme
- PROSAAS antikoerper, SAAS antikoerper, Saas antikoerper, AI848336 antikoerper, KEP antikoerper, PEN antikoerper, PEN19 antikoerper, PEN20 antikoerper, Pan3 antikoerper, SAASCT antikoerper, bLEN antikoerper, lLEN antikoerper, proSAAS antikoerper, proprotein convertase subtilisin/kexin type 1 inhibitor antikoerper, PCSK1N antikoerper, Pcsk1n antikoerper
- Hintergrund
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Pcsk1n may function in the control of the neuroendocrine secretory pathway. It is proposed to be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 87 kDa form but not the autocatalytically derived 65 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. Pcsk1n may control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known.
Alias Symbols: Saas
Protein Interaction Partner: STXBP5L,
Protein Size: 260 - Molekulargewicht
- 28 kDa
- Gen-ID
- 246333
- NCBI Accession
- NM_019279, NP_062152
- UniProt
- Q9QXU9
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