IL7R Antikörper (Middle Region)

Produktnummer ABIN617087

Produktdetails anti-IL7R Antikörper

Target: IL7R (Interleukin 7 Receptor (IL7R))

Bindungsspezifität: Middle Region

Reaktivität: Human, Pferd, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL7R Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: ESFLDCQIHR VDDIQARDEV EGFLQDTFPQ QLEESEKQRL GGDVQSPNCP

Homologie: Dog: 92%, Horse: 83%, Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against IL7R. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human IL7R

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 459 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu IL7R

Target: IL7R (Interleukin 7 Receptor (IL7R))

Andere Bezeichnung: IL7R (IL7R Produkte)

Synonyme: IL7R antikoerper, CD127 antikoerper, IL-7Ralpha antikoerper, CDW127 antikoerper, IL-7R-alpha antikoerper, IL7RA antikoerper, ILRA antikoerper, IL-7RA antikoerper, interleukin 7 receptor antikoerper, IL7R antikoerper, Il7r antikoerper

Hintergrund: The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID).
Alias Symbols: CD127, CDW127, IL-7R-alpha, IL7RA, ILRA
Protein Interaction Partner: KIT, JAK3, SNRPG, SNRPD3, SNRPD2, SNRPD1, SNRPB, SNRPA, SNRNP70, SRSF3, SAFB, RPS20, RPS3, RPL31, RPL29, RPL30, RPL22, RPL18, RPL15, RPL8, RPL7, RPL6, RBM3, PURB, PURA, PTMA, PTBP1, EIF2AK2, YBX1, NONO, NCL, MAP4, RPSA, ILF3, ILF2, HNRNPU, HNRNPL, HNRNPH3
Protein Size: 459

Molekulargewicht: 49 kDa

Gen-ID: 3575

NCBI Accession: NM_002185, NP_002176

UniProt: P16871

Pathways: JAK-STAT Signalweg, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Regulation of Cell Size