ERCC8 Antikörper (Middle Region)
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- Target Alle ERCC8 Antikörper anzeigen
- ERCC8 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8))
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Bindungsspezifität
- Middle Region
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser ERCC8 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- FQELYSGSRD CNILAWVPSL YEPVPDDDET TTKSQLNPAF EDAWSSSDEE
- Produktmerkmale
- This is a rabbit polyclonal antibody against ERCC8. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human ERCC8
- Top Product
- Discover our top product ERCC8 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 396 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- ERCC8 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8))
- Andere Bezeichnung
- ERCC8 (ERCC8 Produkte)
- Synonyme
- zgc:103550 antikoerper, CKN1 antikoerper, CSA antikoerper, UVSS2 antikoerper, Ckn1 antikoerper, 2410022P04Rik antikoerper, 2810431L23Rik antikoerper, 4631412O06Rik antikoerper, B130065P18Rik antikoerper, Csa antikoerper, excision repair cross-complementation group 8 antikoerper, ERCC excision repair 8, CSA ubiquitin ligase complex subunit antikoerper, excision repaiross-complementing rodent repair deficiency, complementation group 8 antikoerper, ercc8 antikoerper, ERCC8 antikoerper, Ercc8 antikoerper
- Hintergrund
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ERCC8 is a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes.
Alias Symbols: CKN1, CSA
Protein Interaction Partner: CUL4A, CUL4B, DDB1, RUVBL2, ZNF24, PCNA, H1F0, ERCC6, UVSSA, DDA1, RFWD2, COPS4, COPS6, COPS3, TOP1, TP53, SSBP1, OGG1, MDM2, GTF2H2, CUL5, GPS1, DDB2, COPS2, COPS7A, COPS5, COPS8, RBX1, POLR2A, HMGN1, EP300, UBC, CSNK2B, XAB2, UQCRQ, CBR1,
Protein Size: 396 - Molekulargewicht
- 44 kDa
- Gen-ID
- 1161
- NCBI Accession
- NM_000082, NP_000073
- UniProt
- Q13216
- Pathways
- DNA Reparatur, Positive Regulation of Response to DNA Damage Stimulus
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