PSME1 Antikörper (Middle Region)

Produktnummer ABIN2787720

Produktdetails anti-PSME1 Antikörper

Target: PSME1 (Proteasome (Prosome, Macropain) Activator Subunit 1 (PA28 Alpha) (PSME1))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Hund, Schwein, Rind (Kuh), Kaninchen, Meerschweinchen, Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PSME1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: KEKEERKKQQ EKEDKDEKKK GEDEDKGPPC GPVNCNEKIV VLLQRLKPEI

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 93%, Rat: 93%, Yeast: 83%

Produktmerkmale: This is a rabbit polyclonal antibody against PSME1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PSME1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 250 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PSME1

Target: PSME1 (Proteasome (Prosome, Macropain) Activator Subunit 1 (PA28 Alpha) (PSME1))

Andere Bezeichnung: PSME1 (PSME1 Produkte)

Synonyme: fk89d05 antikoerper, wu:fk89d05 antikoerper, IFI5111 antikoerper, PA28A antikoerper, PA28alpha antikoerper, REGalpha antikoerper, AW413925 antikoerper, PA28a antikoerper, proteasome activator subunit 1 antikoerper, proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) antikoerper, psme1 antikoerper, PSME1 antikoerper, Psme1 antikoerper

Hintergrund: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Two transcripts encoding different isoforms have been identified.The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Two transcripts encoding different isoforms have been identified.
Alias Symbols: IFI5111, MGC8628, PA28A, PA28alpha, REGalpha
Protein Interaction Partner: HUWE1, PSME1, NAA10, PSMD14, SHFM1, UBC, PSME2, ADRM1, PSMA1, KIF5B, PARK2, BAG3, UBL7, PSRC1, PARVB, PHPT1, PRDX3, NUBP2, USP5, RBBP6, PSMD12, PSMD1, PSMC4, PSMC2, PSMB3, PSMB2, PSMB1, PSMA7, PSMA6, PSMA3, APP, OXCT1, CSE1L, GRB2, UBD, PSMD6, TUBG1, PSMB
Protein Size: 250

Molekulargewicht: 28 kDa

Gen-ID: 5720

NCBI Accession: NM_176783, NP_788955

UniProt: Q06323

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA