COL1A2 Antikörper (Middle Region)

Produktnummer ABIN2787684

Produktdetails anti-COL1A2 Antikörper

Target: COL1A2 (Collagen, Type I, alpha 2 (COL1A2))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Hund, Kaninchen, Rind (Kuh), Zebrafisch (Danio rerio), Ziege, Meerschweinchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COL1A2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: PGSVGPAGPR GPAGPSGPAG KDGRTGHPGT VGPAGIRGPQ GHQGPAGPPG

Homologie: Cow: 100%, Dog: 93%, Goat: 79%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 79%, Rabbit: 86%, Rat: 100%, Zebrafish: 85%

Produktmerkmale: This is a rabbit polyclonal antibody against COL1A2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human COL1A2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1366 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu COL1A2

Target: COL1A2 (Collagen, Type I, alpha 2 (COL1A2))

Andere Bezeichnung: COL1A2 (COL1A2 Produkte)

Synonyme: AA960264 antikoerper, AI325291 antikoerper, Col1a-2 antikoerper, Cola-2 antikoerper, Cola2 antikoerper, oim antikoerper, OI4 antikoerper, Gas-6 antikoerper, alpha2(I) antikoerper, hm:zehn2357 antikoerper, wu:fa98d05 antikoerper, wu:fa99g10 antikoerper, wu:fb04c08 antikoerper, wu:fb11d06 antikoerper, zehn2357 antikoerper, coagulation factor II, thrombin antikoerper, collagen, type I, alpha 2 antikoerper, collagen type I alpha 2 chain antikoerper, collagen type I alpha 2 L homeolog antikoerper, growth arrest specific 6 antikoerper, F2 antikoerper, Col1a2 antikoerper, col1a2.L antikoerper, COL1A2 antikoerper, Gas6 antikoerper, col1a2 antikoerper

Hintergrund: COL1A2 is the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity.This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: OI4
Protein Interaction Partner: UBQLN1, SGTA, PDGFB, PDGFA, COL1A1, PAN2, LIG4, MYOC, SHBG, UBC, MMP9, COL5A3, CD44, APP, P4HB, ITGA2B, TGFBI, LUM, BGN, VWF, ITGA2, SPARC, CD36, ITGB3, FN1, DCN, CD93,
Protein Size: 1366

Molekulargewicht: 150 kDa

Gen-ID: 1278

NCBI Accession: NM_000089, NP_000080

UniProt: P08123