SAV1 Antikörper (C-Term)
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- Target Alle SAV1 Antikörper anzeigen
- SAV1 (Salvador Homolog 1 (SAV1))
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Bindungsspezifität
- C-Term
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Reaktivität
- Human, Maus, Ratte, Hund, Pferd, Schwein, Kaninchen, Rind (Kuh)
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser SAV1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- PCAPSVPRYD QPPPITYQPQ QTERNQSLLV PANPYHTAEI PDWLQVYARA
- Homologie
- Cow: 93%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%
- Produktmerkmale
- This is a rabbit polyclonal antibody against Sav1. It was validated on Western Blot.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C-terminal region of Sav1
- Top Product
- Discover our top product SAV1 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 386 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- SAV1 (Salvador Homolog 1 (SAV1))
- Andere Bezeichnung
- Sav1 (SAV1 Produkte)
- Synonyme
- SAV antikoerper, WW45 antikoerper, WWP4 antikoerper, 1700040G09Rik antikoerper, Salv antikoerper, Sav antikoerper, Wwp3 antikoerper, Wwp4 antikoerper, salvador family WW domain containing protein 1 antikoerper, salvador family WW domain containing 1 antikoerper, SAV1 antikoerper, Sav1 antikoerper
- Hintergrund
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Sav1 is a regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.
Alias Symbols: 1700040G09Rik, Sav, WW45, Wwp3, Wwp4
Protein Size: 386 - Molekulargewicht
- 42 kDa
- Gen-ID
- 64010
- NCBI Accession
- NM_022028, NP_071311
- UniProt
- Q8VEB2
- Pathways
- Stem Cell Maintenance
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