Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

SAV1 Antikörper (AA 1-210)

SAV1 Reaktivität: Human WB, ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7166095
  • Target Alle SAV1 Antikörper anzeigen
    SAV1 (Salvador Homolog 1 (SAV1))
    Bindungsspezifität
    • 8
    • 8
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-210
    Reaktivität
    • 30
    • 7
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 24
    • 6
    • 1
    Kaninchen
    Klonalität
    • 28
    • 3
    Polyklonal
    Konjugat
    • 21
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser SAV1 Antikörper ist unkonjugiert
    Applikation
    • 28
    • 18
    • 6
    • 4
    • 4
    • 2
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    Kreuzreaktivität
    Human
    Aufreinigung
    Antigen Affinity Purified
    Immunogen
    Recombinant Human Protein salvador homolog 1 protein (1-210AA)
    Isotyp
    IgG
    Top Product
    Discover our top product SAV1 Primärantikörper
  • Applikationshinweise
    Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:500, IF:1:50-1:200,
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    SAV1 (Salvador Homolog 1 (SAV1))
    Andere Bezeichnung
    SAV1 (SAV1 Produkte)
    Synonyme
    SAV antikoerper, WW45 antikoerper, WWP4 antikoerper, 1700040G09Rik antikoerper, Salv antikoerper, Sav antikoerper, Wwp3 antikoerper, Wwp4 antikoerper, salvador family WW domain containing protein 1 antikoerper, salvador family WW domain containing 1 antikoerper, SAV1 antikoerper, Sav1 antikoerper
    Hintergrund

    Background: Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.

    Aliases: 1700040G09Rik antibody, 45 kDa WW domain protein antibody, hWW 45 antibody, hWW45 antibody, Protein salvador homolog 1 antibody, salvador family WW domain containing protein 1 antibody, salvador homolog 1 (Drosophila) antibody, Salvador homolog 1 antibody, Salvador, Drosophila, homolog of antibody, SAV 1 antibody, SAV antibody, SAV1 antibody, SAV1_HUMAN antibody, WW 45 antibody, WW domain containing antibody, WW domain-containing adaptor 45 antibody, WW domain-containing protein, 45-KD antibody, WW45 antibody, WW45 protein antibody, WWP 4 antibody, WWP4 antibody

    UniProt
    Q9H4B6
    Pathways
    Stem Cell Maintenance
Sie sind hier: