RFC4 Antikörper (Middle Region)

Produktnummer ABIN405791

Produktdetails anti-RFC4 Antikörper

Target: RFC4 (Replication Factor C (Activator 1) 4, 37kDa (RFC4))

Bindungsspezifität: Middle Region

Reaktivität: Human, Ratte, Maus, Hund, Schwein, Rind (Kuh), Pferd, Meerschweinchen, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RFC4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: DKLEAVVKDL IDEGHAATQL VNQLHDVVVE NNLSDKQKSI ITEKLAEVDK

Homologie: Cow: 93%, Dog: 86%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 93%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against RFC4. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human RFC4

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 363 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu RFC4

Target: RFC4 (Replication Factor C (Activator 1) 4, 37kDa (RFC4))

Andere Bezeichnung: RFC4 (RFC4 Produkte)

Synonyme: 44.t00003 antikoerper, 21.m03053 antikoerper, rfc4 antikoerper, A1 antikoerper, AI894123 antikoerper, AU040575 antikoerper, RFC37 antikoerper, rfc2 antikoerper, replication factor C subunit 4 antikoerper, Replication factor C subunit 4 antikoerper, replication factor C (activator 1) 4 antikoerper, replication factor C subunit 4 L homeolog antikoerper, PFL2005w antikoerper, EHI_167150 antikoerper, TP03_0432 antikoerper, Tb11.01.1310 antikoerper, BBOV_IV002210 antikoerper, rfc4 antikoerper, rfc-4 antikoerper, Rfc4 antikoerper, RFC4 antikoerper, rfc4.L antikoerper

Hintergrund: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template.The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported.
Alias Symbols: A1, MGC27291, RFC37
Protein Interaction Partner: RNF41, UBC, RFC5, PCNA, TP53, SUMO2, RPA3, RPA2, RPA1, RNF2, C14orf166, RTCB, RPL26L1, DIMT1, NELFB, EDC4, IGF2BP3, EIF2B2, EIF2B3, YBX3, QARS, NMT1, HNRNPM, MRE11A, ILF2, HNRNPU, FLII, FKBP3, EPRS, DHX9, DDX1, ABCF1, PARK2, TARDBP, MPG, RFC2, MYC, FN1, P
Protein Size: 363

Molekulargewicht: 40 kDa

Gen-ID: 5984

NCBI Accession: NM_002916, NP_002907

UniProt: P35249

Pathways: Telomere Maintenance, DNA Reparatur, DNA Replication, Synthesis of DNA