ATP2B3 Antikörper (N-Term)

Produktnummer ABIN2781842

Produktdetails anti-ATP2B3 Antikörper

Target: ATP2B3 (ATPase, Ca++ Transporting, Plasma Membrane 3 (ATP2B3))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Meerschweinchen, Pferd, Hund, Kaninchen, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATP2B3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: GDMANSSIEF HPKPQQQRDV PQAGGFGCTL AELRTLMELR GAEALQKIEE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 79%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 86%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against ATP2B3. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human ATP2B3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1220 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu ATP2B3

Target: ATP2B3 (ATPase, Ca++ Transporting, Plasma Membrane 3 (ATP2B3))

Andere Bezeichnung: ATP2B3 (ATP2B3 Produkte)

Synonyme: PMCA3 antikoerper, PMCA3a antikoerper, SCAX1 antikoerper, atp2b3 antikoerper, pmca3a antikoerper, zgc:92885 antikoerper, 6430519O13Rik antikoerper, Pmca3 antikoerper, ATPase plasma membrane Ca2+ transporting 3 antikoerper, ATPase, Ca++ transporting, plasma membrane 3a antikoerper, ATPase, Ca++ transporting, plasma membrane 3 antikoerper, plasma membrane calcium-transporting ATPase 2 antikoerper, ATP2B3 antikoerper, atp2b3a antikoerper, Atp2b3 antikoerper, atp2b3 antikoerper, LOC100639471 antikoerper

Hintergrund: ATP2B3 gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. ATP2B3 is the plasma membrane calcium ATPase isoform 3.The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 3. Alternatively spliced transcript variants encoding different isoforms have been identified.
Alias Symbols: PMCA3, PMCA3a
Protein Interaction Partner: LGR4, PARK2, UBC, TERF2,
Protein Size: 1220

Molekulargewicht: 134 kDa

Gen-ID: 492

NCBI Accession: NM_001001344, NP_001001344

UniProt: Q16720

Pathways: Ribonucleoside Biosynthetic Process