WT1 Antikörper (N-Term)

Produktnummer ABIN2780339

Produktdetails anti-WT1 Antikörper

Target: WT1 (Wilms Tumor 1 (WT1))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: PASQHTLRSG PGCLQQPEQQ GVRDPGGIWA KLGAAEASAE RLQGRRSRGA

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against WT1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human WT1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 497 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu WT1

Target: WT1 (Wilms Tumor 1 (WT1))

Andere Bezeichnung: WT1 (WT1 Produkte)

Synonyme: AWT1 antikoerper, EWS-WT1 antikoerper, GUD antikoerper, NPHS4 antikoerper, WAGR antikoerper, WIT-2 antikoerper, WT33 antikoerper, CWT1 antikoerper, WT1 antikoerper, XWT1a antikoerper, wt-1 antikoerper, wt1 antikoerper, xWT1 antikoerper, WT-1 antikoerper, gud antikoerper, wagr antikoerper, wt33 antikoerper, xwt1 antikoerper, wit-2 antikoerper, si:ch211-160j6.3 antikoerper, zgc:152697 antikoerper, D630046I19Rik antikoerper, Wt-1 antikoerper, XWT1b antikoerper, XeWT1 antikoerper, Wilms tumor 1 antikoerper, Wilms tumor 1 S homeolog antikoerper, wilms tumor 1b antikoerper, Wilms tumor protein antikoerper, Wilms tumor 1 homolog antikoerper, Wilms tumor 1 L homeolog antikoerper, WT1 antikoerper, wt1.S antikoerper, wt1 antikoerper, wt1b antikoerper, Wt1 antikoerper, wt1.L antikoerper

Hintergrund: WT1 is a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilm's tumors. Multiple transcript variants, resulting from alternative splicing at two coding exons, have been well characterized. There is also evidence for the use of non-AUG (CUG) translation initiation site upstream of, and in-frame with the first AUG, leading to additional isoforms.
Alias Symbols: AWT1, GUD, WAGR, WIT-2, WT33, NPHS4, EWS-WT1
Protein Interaction Partner: KRTAP10-3, KRTAP10-8, KRT40, EGR1, MDM2, DVL3, CIAO1, TP53, HSPA4, TAOK1, NPM3, ZNF205, SUZ12, MEN1, EZH2, DNMT1, WTIP, WTAP, PAWR, UBE2I, TP63, FHL2, TP73, PRKACA, CREBBP, U2AF2, PAX2, AREG,
Protein Size: 497

Molekulargewicht: 54 kDa

Gen-ID: 7490

NCBI Accession: NM_000378, NP_000369

UniProt: E9PMK7

Pathways: Tube Formation