ZFPM1 Antikörper (Middle Region)

Produktnummer ABIN2779499

Produktdetails anti-ZFPM1 Antikörper

Target: ZFPM1 (Zinc Finger Protein, Multitype 1 (ZFPM1))

Bindungsspezifität: Middle Region

Reaktivität: Human, Ratte, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZFPM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: PPPPPPGHAP APESPRPGSG SGSGPGLAPA RSPGPAADGP IDLSKKPRRP

Homologie: Cow: 91%, Human: 100%, Rat: 83%

Produktmerkmale: This is a rabbit polyclonal antibody against ZFPM1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ZFPM1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1006 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-ZFPM1 Antikörper (ABIN2779499)

Sugiyama, Tanaka, Kitajima, Zheng, Yen, Murotani, Yamatodani, Nakano: "Differential context-dependent effects of friend of GATA-1 (FOG-1) on mast-cell development and differentiation." in: Blood, Vol. 111, Issue 4, pp. 1924-32, (2008) (PubMed).

Details zu ZFPM1

Target: ZFPM1 (Zinc Finger Protein, Multitype 1 (ZFPM1))

Andere Bezeichnung: ZFPM1 (ZFPM1 Produkte)

Synonyme: FOG antikoerper, FOG1 antikoerper, ZC2HC11A antikoerper, ZNF408 antikoerper, ZNF89A antikoerper, Fog1 antikoerper, Xfog antikoerper, fog antikoerper, fog-1 antikoerper, fog1 antikoerper, FOG-1 antikoerper, si:dkey-20g6.1 antikoerper, si:dkey-38l12.1 antikoerper, ZNF469 antikoerper, ZFPM1 antikoerper, zinc finger protein, FOG family member 1 antikoerper, zinc finger protein, multitype 1 antikoerper, zinc finger protein, FOG family member 1 L homeolog antikoerper, ZFPM1 antikoerper, Zfpm1 antikoerper, zfpm1.L antikoerper, zfpm1 antikoerper

Hintergrund: ZFPM1 is a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM1 is an essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. ZFPM1 may be involved in regulation of some genes in gonads. ZFPM1 may also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.
Alias Symbols: FOG, FOG1, ZNF408, ZNF89A
Protein Interaction Partner: GSK3B, CTBP2, TRIM21, MTA1, RBBP4, Rb1, GATA1, GIPC1, TOP3B, GATA2,
Protein Size: 1006

Molekulargewicht: 105 kDa

Gen-ID: 161882

NCBI Accession: NM_153813, NP_722520

UniProt: Q8IX07