SSB Antikörper (N-Term)

Produktnummer ABIN183960

Produktdetails anti-SSB Antikörper

Target: SSB (Sjogren Syndrome Antigen B (SSB))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Hund, Pferd, Kaninchen, Rind (Kuh), Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SSB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: ISEDKTKIRR SPSKPLPEVT DEYKNDVKNR SVYIKGFPTD ATLDDIKEWL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against SSB. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SSB

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 408 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-SSB Antikörper (ABIN183960)

Teplova, Yuan, Phan, Malinina, Ilin, Teplov, Patel: "Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen." in: Molecular cell, Vol. 21, Issue 1, pp. 75-85, (2006) (PubMed).

Details zu SSB

Target: SSB (Sjogren Syndrome Antigen B (SSB))

Andere Bezeichnung: SSB (SSB Produkte)

Synonyme: LARP3 antikoerper, La antikoerper, lab1 antikoerper, larp3 antikoerper, ssb antikoerper, Mt-SSB antikoerper, MtSSB antikoerper, Ssbp1 antikoerper, SS-B antikoerper, laa-a antikoerper, ssb-a antikoerper, ssb-b antikoerper, wu:fb17f11 antikoerper, zgc:55588 antikoerper, Sjogren syndrome antigen B antikoerper, Sjogren syndrome antigen B L homeolog antikoerper, single stranded DNA binding protein 1 antikoerper, Sjogren syndrome antigen B S homeolog antikoerper, Sjogren syndrome antigen B (autoantigen La) antikoerper, SSB antikoerper, ssb.L antikoerper, SSBP1 antikoerper, Ssb antikoerper, ssb.S antikoerper, ssb antikoerper

Hintergrund: SSB is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. SSB protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome and systemic lupus erythematosus.La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III (see MIM 606007)-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome (MIM 270150) and systemic lupus erythematosus (SLE, MIM 152700) (Teplova et al., 2006).[supplied by OMIM].
Alias Symbols: La, LARP3
Protein Interaction Partner: HUWE1, UBC, MDM2, LIN28A, BMI1, SUZ12, RNF2, rev, NPLOC4, DNM1L, UBA2, ANP32A, VBP1, RABGGTA, PPP2CA, KARS, CTTN, TARDBP, SOX2, HMGA1, ARFGEF1, NCL, GZMH, CSNK2B, CSNK2A1, HCVgp1, CBX6, SPIB, IL7R, IFIT3, FN1, SMURF1, BARD1, PAXIP1, APP, TROVE2, XIAP, CAN
Protein Size: 408

Molekulargewicht: 45 kDa

Gen-ID: 6741

NCBI Accession: NM_003142, NP_003133

UniProt: P05455