SSB Antikörper (N-Term)

Produktnummer ABIN2778846

Zitiert in 1 Publikation. Der Kaninchen Polyklonal anti-SSB Antikörper (ABIN2778846) detektiert spezifisch SSB in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus, Ratte, Hund, Pferd, Rind (Kuh), Kaninchen und Meerschweinchen.

Kurzübersicht für SSB Antikörper (N-Term) (ABIN2778846)

Target: SSB (Sjogren Syndrome Antigen B (SSB))

Reaktivität: Human, Maus, Ratte, Hund, Pferd, Rind (Kuh), Kaninchen, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SSB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-SSB Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: SSB Antibody - N-terminal region

Sequenz: ISEDKTKIRR SPSKPLPEVT DEYKNDVKNR SVYIKGFPTD ATLDDIKEWL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against SSB. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SSB

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8111829

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-SSB Antikörper (ABIN2778846)

Teplova, Yuan, Phan, Malinina, Ilin, Teplov, Patel: "Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen." in: Molecular cell, Vol. 21, Issue 1, pp. 75-85, (2006) (PubMed).

Details zu SSB

Target: SSB (Sjogren Syndrome Antigen B (SSB))

Andere Bezeichnung: SSB

Hintergrund:

Background Information: SSB is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. SSB protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome and systemic lupus erythematosus.La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III (see MIM 606007)-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome (MIM 270150) and systemic lupus erythematosus (SLE, MIM 152700) (Teplova et al., 2006).[supplied by OMIM].

Gene Name: Sjogren syndrome antigen B (autoantigen La)

Alternative Symbols: La, LARP3, La/SSB

Protein Name: Lupus La protein

Molekulargewicht: 45kDa

Gen-ID: 6741

NCBI Accession: NP_003133

UniProt: P05455