MBNL2 Antikörper (Middle Region)

Produktnummer ABIN2776541

Produktdetails anti-MBNL2 Antikörper

Target: MBNL2 (Muscleblind-Like 2 (MBNL2))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Kaninchen, Zebrafisch (Danio rerio), Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MBNL2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: IACFDSLKGR CSRENCKYLH PPTHLKTQLE INGRNNLIQQ KTAAAMLAQQ

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against Mbnl2. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of RAT Mbnl2

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MBNL2

Target: MBNL2 (Muscleblind-Like 2 (MBNL2))

Andere Bezeichnung: Mbnl2 (MBNL2 Produkte)

Synonyme: 1110002M11Rik antikoerper, AI047808 antikoerper, AI837313 antikoerper, AI849185 antikoerper, AL118326 antikoerper, MBLL antikoerper, R75232 antikoerper, mKIAA4072 antikoerper, wu:fj89c04 antikoerper, MBLL39 antikoerper, PRO2032 antikoerper, muscleblind like splicing factor 2 antikoerper, muscleblind-like splicing regulator 2 antikoerper, muscleblind like splicing regulator 2 antikoerper, Mbnl2 antikoerper, mbnl2 antikoerper, MBNL2 antikoerper

Hintergrund: Mbnl2 mediates pre-mRNA alternative splicing regulation. It acts either as activator or repressor of splicing on specific pre-mRNA targets. It inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. It antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. It binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. It seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. It may play a role in myotonic dystrophy pathophysiology (DM).
Protein Size: 378

Molekulargewicht: 41 kDa

Gen-ID: 680445

UniProt: F2Z3T4