MLH3 Antikörper (Middle Region)

Produktnummer ABIN2775396

Produktdetails anti-MLH3 Antikörper

Target: MLH3 (MutL Homolog 3 (MLH3))

Bindungsspezifität: Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MLH3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: SMQVLQQVDN KFIACLMSTK TEENGEADSY EKQQAQGSGR KKLLSSTLIP

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against MLH3. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human MLH3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1429 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu MLH3

Target: MLH3 (MutL Homolog 3 (MLH3))

Andere Bezeichnung: MLH3 (MLH3 Produkte)

Synonyme: AV125803 antikoerper, BB126472 antikoerper, MGC80774 antikoerper, MLH3 antikoerper, HNPCC7 antikoerper, mutL homolog 3 antikoerper, mutL homolog 3 L homeolog antikoerper, Mlh3 antikoerper, mlh3.L antikoerper, MLH3 antikoerper, mlh3 antikoerper

Hintergrund: This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. MLH3 functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.
Alias Symbols: HNPCC7, MGC138372
Protein Interaction Partner: MLH1, MYC, FAN1, AR, MLH3, MSH4,
Protein Size: 1429

Molekulargewicht: 161 kDa

Gen-ID: 27030

NCBI Accession: NM_014381, NP_055196

UniProt: Q2M1Z1

Pathways: Chromatin Binding