MLH3 Antikörper (AA 521-570)

Produktnummer ABIN1534469

Der Kaninchen Polyklonal anti-MLH3 Antikörper (ABIN1534469) detektiert spezifisch MLH3 in WB, ELISA, IHC und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für MLH3 Antikörper (AA 521-570) (ABIN1534469)

Target: MLH3 (MutL Homolog 3 (MLH3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MLH3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-MLH3 Antikörper

Bindungsspezifität: AA 521-570

Verwendungszweck: MLH3 Antibody

Spezifität: MLH3 Polyclonal Antibody detects endogenous levels of MLH3 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human MLH3. AA range:521-570

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu MLH3

Target: MLH3 (MutL Homolog 3 (MLH3))

Andere Bezeichnung: MLH3

Hintergrund:

Synonyms: MLH3, DNA mismatch repair protein Mlh3, MutL protein homolog 3

Background: This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination.The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008],

Gene Name: MLH3

Protein Name: DNA mismatch repair protein Mlh3

Molekulargewicht: 163 kDa

Gen-ID: 27030

OMIM: 114500

UniProt: Q9UHC1

Pathways: Chromatin Binding