KIR3DL1 Antikörper (Middle Region)

Produktnummer ABIN2775346

Produktdetails anti-KIR3DL1 Antikörper

Target: KIR3DL1 (Killer Cell Immunoglobulin-Like Receptor, three Domains, Long Cytoplasmic Tail, 1 (KIR3DL1))

Bindungsspezifität: Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KIR3DL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: EHFFLHKEGI SKDPSRLVGQ IHDGVSKANF SIGPMMLALA GTYRCYGSVT

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against KIR3DL1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human KIR3DL1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeat freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu KIR3DL1

Target: KIR3DL1 (Killer Cell Immunoglobulin-Like Receptor, three Domains, Long Cytoplasmic Tail, 1 (KIR3DL1))

Andere Bezeichnung: KIR3DL1 (KIR3DL1 Produkte)

Synonyme: KIR3DL1 antikoerper, KIR3DL3 antikoerper, CD158E1 antikoerper, KIR antikoerper, KIR3DL1/S1 antikoerper, NKAT3 antikoerper, NKB1 antikoerper, NKB1B antikoerper, Kirl1 antikoerper, Kirl2 antikoerper, Krl1 antikoerper, killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 antikoerper, uncharacterized LOC100437736 antikoerper, killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1 antikoerper, KIR3DL1 antikoerper, LOC100437736 antikoerper, Kir3dl1 antikoerper

Hintergrund: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules, thus, KIR proteins are thought to play an important role in regulation of the immune response.
Alias Symbols: CD158E1, KIR, KIR3DL1/S1, NKAT3, NKB1, NKB1B
Protein Interaction Partner: env, RPS6KB1, HLA-B, CDK3,
Protein Size: 444

Molekulargewicht: 48 kDa

Gen-ID: 3811

NCBI Accession: NM_013289, NP_037421

UniProt: P43629