HACE1 antikoerper, 1700042J16Rik antikoerper, A730034A22Rik antikoerper, BC025474 antikoerper, HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 antikoerper, HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 L homeolog antikoerper, HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 antikoerper, HACE1 antikoerper, hace1 antikoerper, hace1.L antikoerper, Hace1 antikoerper
Hintergrund
HACE1 is a E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. It acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. It acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. HACE1 specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. It may also act as a transcription regulator via its interaction with RARB. Alias Symbols: - Protein Interaction Partner: UBE2L3, UBC, OPTN, Unc45b, Flna, Actn1, Cald1, Lima1, Actn4, Tpm3, Tmod3, Coro1c, Vim, Vcl, Tubb5, Tubb4a, Tpm2, Tpm1, Tcp1, Plec, Sqstm1, Npm1, Myh9, Marcks, Hspa9, Hsp90ab1, Hspd1, Hspa8, Fhl1, Csrp1, Cnn2, Cct8, Serpinh1, Capzb, Capza2, Capza1, Actg1, Protein Size: 694