HACE1 Antikörper

Produktnummer ABIN6242379

Produktdetails anti-HACE1 Antikörper

Target: HACE1 (HECT Domain and Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HACE1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This HACE1 antibody is generated from a mouse immunized with a recombinant protein from the human region of human HACE1.

Klon: 1854CT757-66-47

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: WB: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu HACE1

Target: HACE1 (HECT Domain and Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1))

Andere Bezeichnung: HACE1 (HACE1 Produkte)

Synonyme: HACE1 antikoerper, 1700042J16Rik antikoerper, A730034A22Rik antikoerper, BC025474 antikoerper, HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 antikoerper, HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 L homeolog antikoerper, HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 antikoerper, HACE1 antikoerper, hace1 antikoerper, hace1.L antikoerper, Hace1 antikoerper

Hintergrund: E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.

Molekulargewicht: 102342

UniProt: Q8IYU2