FYN Antikörper (AA 240-290)

Produktnummer ABIN2746628

Produktdetails anti-FYN Antikörper

Target: FYN (FYN Oncogene Related To SRC, FGR, YES (FYN))

Bindungsspezifität: AA 240-290

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FYN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: The antibody labels a strong band of Fyn at 64 kDa in ABIN1741653 samples and in other cancer cell lines.

Kreuzreaktivität: Maus, Ratte (Rattus)

Kreuzreaktivität (Details): The antibody does not cross react to any other cellular protein.

Produktmerkmale: Fyn selective antibodies were generated against a peptide taken from the human protein. The Fyn-selective antibodies are affinity purified on an immobilized antigen based affinity matrix, the isolated antibodies were then stabilized in antibody stabilization buffer for long-term storage. The Fyn-selective antibodies are fully characterized for applications in western blotting and ELISA at the recommended dilutions. The supplier provides Fyn Western blot positive control samples in ready-to-use SDS-PAGE sample buffer. Limited quantities of antigenic blocking peptide for Fyn antibody is also available, please inquire before ordering.

Aufreinigung: Affinity Purified

Immunogen: Synthetic peptide taken within amino acid region 240-290 on human Fyn protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Synonyms: Proto-oncogene c-Fyn, p59, Src-like-kinase, SLK, Protooncogene Syn.P59-Fyn

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.55-0.75 μg/μL

Handhabung: Working solutions of antibodies in buffer should be filtered through 0.45 μm filter after every use for long-term storage.

Lagerung: -20 °C

Informationen zur Lagerung: For long-term storage of keep at -20 °C. We don't recommend storage of very dilute antibody solutions unless they are prepared in specially formulated multi use antibody dilution buffer.

Details zu FYN

Target: FYN (FYN Oncogene Related To SRC, FGR, YES (FYN))

Andere Bezeichnung: FYN (FYN Produkte)

Synonyme: im:6908851 antikoerper, si:dkey-119m7.5 antikoerper, zgc:109996 antikoerper, c-fyn antikoerper, cfyn-a antikoerper, SLK antikoerper, SYN antikoerper, p59-FYN antikoerper, PKC antikoerper, fyn antikoerper, zgc:86720 antikoerper, AI448320 antikoerper, AW552119 antikoerper, FYN proto-oncogene, Src family tyrosine kinase antikoerper, FYN proto-oncogene, Src family tyrosine kinase S homeolog antikoerper, FYN proto-oncogene, Src family tyrosine kinase b antikoerper, FYN proto-oncogene, Src family tyrosine kinase L homeolog antikoerper, FYN proto-oncogene, Src family tyrosine kinase a antikoerper, Fyn proto-oncogene antikoerper, FYN antikoerper, fyn.S antikoerper, fynb antikoerper, fyn.L antikoerper, Fyn antikoerper, fyna antikoerper

Hintergrund: Protein tyrosine kinases are large multigene families which are important mediators of the signaling transduction pathways, responsible for intracellular signal transduction. Tyrosine kinases are a diverse group of cell surface transmembrane proteins that act as receptors for cytokines, growth factors, hormones and other signaling molecules. Receptor tyrosine kinases are expressed in many cell types and play important roles in a wide variety of cellular processes, including growth, differentiation, angiogenesis, metabolism and apoptosis in response to external and internal stimuli. Over-expression and/or structural alteration of tyrosine kinase family members are associated to human cancers. Tumor cells use RTK transduction pathways to achieve tumor growth, angiogenesis and metastasis making it a target in approaches of cancer therapy. Fyn kinase is a 64 kDa protein and one of the 9 members of the Src family kinase (SFK) which are important in the regulation of growth and differentiation of eukaryotic cells. Src-family kinases transduce signals that are involved in the control of a variety of cellular processes, including proliferation, differentiation, motility, and adhesion. Synthesized and N-myristoylated Fyn protein is targeted to the plasma membrane, where it is palmitoylated. Fyn encodes a membraneassociated tyrosine kinase that is implicated in the control of cell growth and it plays a key role in T-cell antigen receptor (TCR) signaling. Dually acetylated Fyn clusters in caveolae-like membrane micro domains and interacts with a variety of other signaling molecules. Fyn's biological functions are diverse and include signaling via the T cell receptor, regulation of brain function and adhesion mediated signaling. It is required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. The human Fyn gene maps to chromosome 6q21 and encodes a 537 amino acid protein.

UniProt: P06241

Pathways: JAK-STAT Signalweg, T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Activated T Cell Proliferation, Thromboxane A2 Receptor Signaling