CYP2C8 Antikörper

Produktnummer ABIN272275

Produktdetails anti-CYP2C8 Antikörper

Target: CYP2C8 (Cytochrome P450, Family 2, Subfamily C, Polypeptide 8 (CYP2C8))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CYP2C8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Spezifität: This antibody detects endogenous levels of CYP2C8/9/18/19 protein. (region surrounding Met136)

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Reinheit: > 95 % pure by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: DO NOT FREEZE!

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu CYP2C8

Target: CYP2C8 (Cytochrome P450, Family 2, Subfamily C, Polypeptide 8 (CYP2C8))

Andere Bezeichnung: CYP2C8 (CYP2C8 Produkte)

Synonyme: CPC8 antikoerper, CYPIIC8 antikoerper, MP-12/MP-20 antikoerper, CYP2C74 antikoerper, cpc8 antikoerper, cyp2c8 antikoerper, cypiic8 antikoerper, mp-12/mp-20 antikoerper, cytochrome P450 family 2 subfamily C member 8 antikoerper, Cytochrome P450 2C8 antikoerper, cytochrome P450, family 2, subfamily C, polypeptide 8 antikoerper, cytochrome P450 family 2 subfamily C member 8 S homeolog antikoerper, CYP2C8 antikoerper, CTN_0597 antikoerper, cyp2c8.1.S antikoerper, cyp2c8.1 antikoerper

Hintergrund: The immunosuppressant cyclosporin A (CsA) forms a trimolecular complex with cyclophilin and calcineurins to inhibit calcineurin phosphatase activity. Cyclophilins are conserved, ubiquitous and abundant cytosolic peptidyl-prolyl cis-trans isomerases that accelerate the isomerization of XaaPro peptide bonds and the refolding of proteins. Human cyclophilin A (CyPA), an intracellular protein of 165 amino acids, is the target of the CsA and is encoded by a single unique gene conserved from yeast to humans. CyPA is known for its involvement in T cell differentiation and proliferation and is highly expressed in brain. CyPA is incorporated into the virion of the type 1 human immunodeficiency virus (HIV-1) via a direct interaction with the capsid domain of the viral Gag polyprotein and is crucial for efficient viral replication.Cyclophilin B (CyPB) is a member of the cyclophilin family with specific N- and C-terminal extensions. Unlike CyPA, CyPB has a signal sequence leading to its translocation in the endoplasmic reticulum. CyPB is secreted in biological fluids such as blood or milk and binds to a specific receptor present on the human lymphoblastic cell line Jurkat and on human peripheral blood lymphocytes.Synonyms: CYPIIC8, Cytochrome P450 2C8, Cytochrome P450 IIC2, Cytochrome P450 MP-12/MP-20, Cytochrome P450 form 1, S-mephenytoin 4-hydroxylase

Molekulargewicht: approx. 60 kDa

Gen-ID: 1558

NCBI Accession: NP_000761

UniProt: P10632