SAE1 Antikörper

Produktnummer ABIN271943

Produktdetails anti-SAE1 Antikörper

Target: SAE1 (SUMO1 Activating Enzyme Subunit 1 (SAE1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SAE1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of AOS1 protein. (region surrounding Leu247)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Reinheit: > 95 % pure by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000. IF: 1: 50-1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: DO NOT FREEZE!

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu SAE1

Target: SAE1 (SUMO1 Activating Enzyme Subunit 1 (SAE1))

Andere Bezeichnung: SAE1 / AOS1 (SAE1 Produkte)

Synonyme: AOS1 antikoerper, HSPC140 antikoerper, SUA1 antikoerper, UBLE1A antikoerper, 2400010M20Rik antikoerper, 2610044L12Rik antikoerper, AL033372 antikoerper, AW743391 antikoerper, D7Ertd177e antikoerper, Sua1 antikoerper, Uble1a antikoerper, Aos1p antikoerper, Sua1p antikoerper, aos antikoerper, sae2a antikoerper, uble1a antikoerper, wu:fa28b04 antikoerper, zgc:86633 antikoerper, SUMO1 activating enzyme subunit 1 antikoerper, SUMO1 activating enzyme subunit 1 L homeolog antikoerper, SAE1 antikoerper, Sae1 antikoerper, sae1.L antikoerper, sae1 antikoerper

Hintergrund: Proteolytic degradation by the ubiquitin (Ub) system is essential for normal cell cycle progression, cellular differentiation and stress responses. Proteins conjugated to Ub are marked for progressive degradation by the 26S Proteosome. Ubiquitin-like 1-activating enzyme E1A, also designated SUMO-1-activating enzyme or AOS-1, belongs to the ubiquitin-activating E1 family of proteins and plays an important role in the first step of the UBL1 conjugation pathway. AOS-1, which is a dimeric enzyme, functions as a UBLI E1 ligase, mediating the ATP-dependent activation of UBL1. It can bind with UBLE1A and UBLE1B to form a heterodimer which can bind UBL1.Synonyms: SUA1, SUMO-activating enzyme subunit 1, UBLE1A, Ubiquitin-like 1-activating enzyme E1A

Molekulargewicht: approx. 38 kDa

Gen-ID: 10055

NCBI Accession: NP_005491

UniProt: Q9UBE0