Reacts with a 35 and a 180 kDa glycosylphosphatidylinositol-anchored glycoprotein present on granulocytes and epithelial cells. Antibody COL-1 was studied as recognizing CD66d and CD66e in the VI Human Leukocyte Differentiation Workshop. CD66 antigens also known as the carcinoembryonic antigen (CEA) family of molecules, are closely related to the immunoglobulin superfamily of glycoproteins. Studies on CD66 Molecules suggest a potential adhesion function in vivo. These molecules exhibit both homophilic and heterophilic ashesion. CEA family members may be involved in transmembrane signalling and activation of neutrophils. Profile of peripheral blood granulocytes analyzed by flow cytometry. Second step staining with biotinylated goat anti-mouse Ig's, third step staining with Streptavidin-PE.
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C
Informationen zur Lagerung
Store undiluted at 4°C.
Siler, Eggensperger, Hand, Milenic, Miller, Houchens, Hinkle, Schlom: "Therapeutic efficacy of a high-affinity anticarcinoembryonic antigen monoclonal antibody (COL-1)." in: Biotechnology therapeutics, Vol. 4, Issue 3-4, pp. 163-81, (1994) (PubMed).
Nagel, Grunert, Kuijpers, Watt, Thompson, Zimmermann: "Genomic organization, splice variants and expression of CGM1, a CD66-related member of the carcinoembryonic antigen gene family." in: European journal of biochemistry / FEBS, Vol. 214, Issue 1, pp. 27-35, (1993) (PubMed).
Thompson, Grunert, Zimmermann: "Carcinoembryonic antigen gene family: molecular biology and clinical perspectives." in: Journal of clinical laboratory analysis, Vol. 5, Issue 5, pp. 344-66, (1991) (PubMed).