KIR2DL3 Antikörper

Produktnummer ABIN2688999

Produktdetails anti-KIR2DL3 Antikörper

Target: KIR2DL3 (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 3 (KIR2DL3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser KIR2DL3 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Marke: BD Pharmingen™

Produktmerkmale: Reacts with a 50 - 58 kDa type I glycoprotein molecule of the killer cell inhibitory receptor (KIR) family of proteins. CD158b has also been known as GLI83, p50.2, or p58.2. CD158b is composed of two extracellular Ig-like domains. It is expressed on a subset of NK cells and it may also be present on rare T cells (either CD3/TCR αβ+, or CD3/TCR γδ+). CD158b regulates NK cell mediated cytolytic activity by interacting with HLA-C alleles (Cw 1, 3, 7 and 8). This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of peripheral blood lymphocytes analyzed by flow cytometry

BD Pharmingen™ Purified Mouse Anti-Human CD158b - Purified - Clone CH-L - Isotype Mouse IgG2b, κ - Reactivity Hu - 0.1 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Klon: CH

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-KIR2DL3 Antikörper (ABIN2688999)

Kim, Chwae, Kim, Choi, Park, Kim: "Molecular basis of HLA-C recognition by p58 natural killer cell inhibitory receptors." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 8, pp. 3875-82, (1997) (PubMed).

Cambiaggi, Orengo, Meazza, Sforzini, Tazzari, Lauria, Raspadori, Zambello, Semenzato, Moretta, Ferrini: "The natural killer-related receptor for HLA-C expressed on T cells from CD3+ lymphoproliferative disease of granular lymphocytes displays either inhibitory or stimulatory function." in: Blood, Vol. 87, Issue 6, pp. 2369-75, (1996) (PubMed).

Colonna, Samaridis: "Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells." in: Science (New York, N.Y.), Vol. 268, Issue 5209, pp. 405-8, (1995) (PubMed).

Ferrini, Cambiaggi, Meazza, Sforzini, Marciano, Mingari, Moretta: "T cell clones expressing the natural killer cell-related p58 receptor molecule display heterogeneity in phenotypic properties and p58 function." in: European journal of immunology, Vol. 24, Issue 10, pp. 2294-8, (1994) (PubMed).

Details zu KIR2DL3

Target: KIR2DL3 (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 3 (KIR2DL3))

Andere Bezeichnung: CD158b (KIR2DL3 Produkte)

Synonyme: CD158B2 antikoerper, CD158b antikoerper, GL183 antikoerper, KIR-023GB antikoerper, KIR-K7b antikoerper, KIR-K7c antikoerper, KIRCL23 antikoerper, NKAT antikoerper, NKAT2 antikoerper, NKAT2A antikoerper, NKAT2B antikoerper, p58 antikoerper, killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3 antikoerper, KIR2DL3 antikoerper

Pathways: Cancer Immune Checkpoints