IL7R Antikörper

Produktnummer ABIN2688947

Produktdetails anti-IL7R Antikörper

Target: IL7R (Interleukin 7 Receptor (IL7R))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IL7R Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Marke: BD Pharmingen™

Produktmerkmale: Monoclonal antibody hIL-7R-M21 reacts with the 60 - 90 kDa glycoprotein, CD127. CD127 is also known as the IL-7 receptor alpha (IL-7Rα). The receptor is a heterodimer composed of the CD127 and the common gamma chain, shared by other cytokine receptors (IL-2R, IL-4R, IL-9R, and IL-15R). CD127 is expressed on thymocytes, T- and B-cell progenitors, mature T cells, and some lymphoid and myeloid cells. In vitro experiments show the expression of CD127 is down-regulated following T cell activation. Studies indicate that the IL-7 Receptor plays an important role in the proliferation and differentiation of mature T cells. Recently, it has been shown that low surface expression of CD127, in combination with intermediate to high suface expression of CD25, the α chain of the IL-2 receptor, can distinguish between human regulatory and conventional CD4+ T cells in human adult and cord blood, lymph nodes and thymus. Profile of CD127 expression on peripheral blood lymphocytes analyzed by flow cytometry. Second step staining with Cat. No. 555988.

BD Pharmingen™ Purified Mouse Anti-Human CD127 - Purified - Clone HIL-7R-M21 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Klon: HIL-7R

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-IL7R Antikörper (ABIN2688947)

Akashi, Traver, Kondo, Weissman: "Lymphoid development from hematopoietic stem cells." in: International journal of hematology, Vol. 69, Issue 4, pp. 217-26, (1999) (PubMed).

Appasamy: "Biological and clinical implications of interleukin-7 and lymphopoiesis." in: Cytokines, cellular & molecular therapy, Vol. 5, Issue 1, pp. 25-39, (1999) (PubMed).

Hofmeister, Khaled, Benbernou, Rajnavolgyi, Muegge, Durum: "Interleukin-7: physiological roles and mechanisms of action." in: Cytokine & growth factor reviews, Vol. 10, Issue 1, pp. 41-60, (1999) (PubMed).

Goodwin, Friend, Ziegler, Jerzy, Falk, Gimpel, Cosman, Dower, March, Namen: "Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily." in: Cell, Vol. 60, Issue 6, pp. 941-51, (1990) (PubMed).

Details zu IL7R

Target: IL7R (Interleukin 7 Receptor (IL7R))

Andere Bezeichnung: CD127 (IL7R Produkte)

Synonyme: IL7R antikoerper, CD127 antikoerper, IL-7Ralpha antikoerper, CDW127 antikoerper, IL-7R-alpha antikoerper, IL7RA antikoerper, ILRA antikoerper, IL-7RA antikoerper, interleukin 7 receptor antikoerper, IL7R antikoerper, Il7r antikoerper

Hintergrund: Synonyms: Interleukin-7 receptor alpha

Pathways: JAK-STAT Signalweg, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Regulation of Cell Size